Protein kinase A: a quirky prototype.

Matthew G Gold
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Abstract

Protein kinase A (PKA) has served as a prototype for establishing kinase fundamentals, including sequence, structure and catalytic mechanism. However, PKA is quirky in some respects. Its regulatory elements are expressed separately, including type I (RI) regulatory subunits that contain unusual disulphide-linked dimerization and docking domains. Benjamin-Zukerman and colleagues report on the RIβ mutation L50R that disrupts this domain to cause neuronal loss and parkinsonism driven by a PKA mutation. They show that PKA catalytic subunits are released more easily from RIβ subunits containing the L50R mutation, adding depth to our understanding of this neurodevelopmental disorder.

蛋白激酶A:一个古怪的原型。
蛋白激酶A (Protein kinase A, PKA)是建立激酶基本原理的原型,包括序列、结构和催化机制。然而,PKA在某些方面很古怪。它的调控元件是单独表达的,包括I型(RI)调控亚基,它含有不寻常的二硫化物连接的二聚化和对接结构域。Benjamin-Zukerman及其同事报道了RIβ突变L50R,该突变破坏该结构域,导致PKA突变驱动的神经元丢失和帕金森病。他们表明,PKA催化亚基更容易从含有L50R突变的RIβ亚基中释放出来,从而加深了我们对这种神经发育障碍的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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