Sex-Specific Association Between Calcium-Channel Blocker Use and B-Type Natriuretic Peptide Levels in Elderly Hypertensive Patients With Heart Failure With Preserved Ejection Fraction.

IF 3.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Circulation Journal Pub Date : 2025-09-25 Epub Date: 2025-07-03 DOI:10.1253/circj.CJ-25-0404

Eisaku Harada, Toshihiro Yamada, Yuji Mizuno, Yuichiro Arima, Koichi Kikuta, Hirofumi Yasue

引用次数: 0

Abstract

Background: The effects of calcium-channel blockers (CCBs) in heart failure with preserved ejection fraction (HFpEF), particularly by sex, remain unclear.

Methods and results: We retrospectively analyzed 412 elderly hypertensive patients with HFpEF (308 women, 104 men). Female CCB users had significantly lower B-type natriuretic peptide (BNP) levels. Multivariable regression showed that CCB use was independently associated with lower BNP, higher EF, and lower tricuspid regurgitation pressure gradient in women, but not in men.

Conclusions: CCB use, particularly amlodipine, may be associated with sex-specific hemodynamic benefits in hypertensive elderly women with HFpEF, independent of blood pressure control.

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老年高血压心力衰竭患者射血分数保留患者钙通道阻滞剂使用与b型利钠肽水平的性别特异性关联

背景：钙通道阻滞剂（CCBs）在保留射血分数（HFpEF）心力衰竭中的作用，特别是按性别区分，目前尚不清楚。方法和结果：我们回顾性分析了412例老年高血压合并HFpEF患者（女性308例，男性104例）。女性CCB使用者的b型利钠肽（BNP）水平明显较低。多变量回归显示，CCB的使用与女性较低的BNP、较高的EF和较低的三尖瓣反流压力梯度独立相关，但与男性无关。结论：CCB的使用，特别是氨氯地平，可能与HFpEF的老年高血压妇女的性别特异性血流动力学益处相关，独立于血压控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Circulation Journal 医学-心血管系统

CiteScore

5.80

自引率

12.10%

发文量

471

审稿时长

1.6 months

期刊介绍： Circulation publishes original research manuscripts, review articles, and other content related to cardiovascular health and disease, including observational studies, clinical trials, epidemiology, health services and outcomes studies, and advances in basic and translational research.