X-ray velocimetry provides temporally and spatially-resolved biomarkers of lung ventilation in small airways disease.

IF 5.8 2区医学 Q1 Medicine

Respiratory Research Pub Date : 2025-07-02 DOI:10.1186/s12931-025-03295-6

Bradley W Richmond, Michael G Lester, Vincent Lui, Jonathan Dusting, Sarath Raju, Gregory I Snell, Jessica B Blackburn, Katrina Douglas, Robert F Miller, Trishul Siddharthan, Andreas Fouras

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引用次数: 0

Abstract

Background: Small airways disease is a feature of many respiratory conditions. Currently available methods of diagnosing small airways lack sensitivity and/or cannot evaluate spatial heterogeneity. New diagnostic strategies for diagnosing small airways disease are needed.

Methods: We determined the regional displacement of lung tissue calculated from fluoroscopic lung images acquired at multiple angles over sequential time points as a surrogate of ventilation. We applied this technique, which we call X-ray velocimetry (XV), to patients with chronic obstructive pulmonary disease (COPD) and impaired spirometry and veterans with deployment-related constrictive bronchiolitis (DR-CB) but preserved spirometry to determine XV-derived biomarkers specific for each condition.

Results: We identified disease- and stage-specific XV biomarkers for COPD patients that correlated with airflow obstruction on spirometry. Further, we identified a set of XV-derived biomarkers that could distinguish veterans with DR-CB from controls despite normal spirometry in most patients from both groups.

Conclusions: XV may provide a safe and widely-available strategy for diagnosing small airways disease while preserving spatial information. Future studies are required to validate the biomarkers described here in larger patient cohorts.

Trial registration: Not required for this study. However, participants enrolled at VUMC were enrolled under ClinicalTrials.gov study NCT04489758 (submitted 07/23/2020).

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x射线测速提供了小气道疾病肺通气的时间和空间分辨生物标志物。

背景：小气道疾病是许多呼吸系统疾病的特征。目前可用的诊断小气道的方法缺乏敏感性和/或不能评估空间异质性。需要新的诊断策略来诊断小气道疾病。方法：我们从连续时间点上多角度获得的透视肺图像中计算肺组织的区域位移，作为通气的替代品。我们将这种称为x射线测速法（XV）的技术应用于慢性阻塞性肺疾病（COPD）患者和肺活量受损的患者以及患有部署相关性缩窄性细支气管炎（DR-CB）的退伍军人，但保留了肺活量测定法，以确定每种疾病特异性的XV衍生生物标志物。结果：我们确定了COPD患者的疾病和分期特异性XV生物标志物，这些标志物与肺活量测定中的气流阻塞相关。此外，我们确定了一组xv衍生的生物标志物，可以将患有DR-CB的退伍军人与对照组区分开来，尽管两组中大多数患者的肺活量正常。结论：XV可能为小气道疾病的诊断提供了一种安全且广泛可用的策略，同时保留了空间信息。未来的研究需要在更大的患者群体中验证本文描述的生物标志物。试验注册：本研究不需要注册。然而，在VUMC入组的参与者是在ClinicalTrials.gov研究NCT04489758（提交于2020年7月23日）下入组的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Research RESPIRATORY SYSTEM-

CiteScore

9.70

自引率

1.70%

发文量

314

审稿时长

4-8 weeks

期刊介绍： Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.