Adipose-Derived Stem Cells at the Crossroads of Obesity and Cancer.

IF 4.2 3区 医学 Q2 CELL & TISSUE ENGINEERING
Ahmad Reza Panahi Meymandi, Abbas Ghaderi
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引用次数: 0

Abstract

Obesity is a major concern for public health and is associated with a higher risk of various types of cancer. Understanding the fundamental mechanisms of this relationship is essential for effective cancer prevention and treatment. Adipose-derived stem cells (ADSCs) are a specialized subtype of mesenchymal stem cells (MSCs) extracted from adipose tissue. These cells have the ability to undergo lineage-specific differentiation into adipocytes, osteoblasts, and chondrocytes. Although ADSCs have significant therapeutic potential, existing studies have indicated that they may facilitate cancer initiation, progression, and recurrence through multiple pathways, including their capacity to facilitate tumor cell proliferation, epithelial-to-mesenchymal transition (EMT), angiogenesis, formation of cancer stem cells (CSCs), immune evasion, and resistance to therapy. Obese individuals have a higher amount of adipose tissue containing an abundance of ADSCs compared to normal individuals, highlighting the possible role of ADSCs in the link between obesity and cancer. In this review, we have explored the effects of ADSCs on cancer initiation, promotion, and progression and put forward a hypothetical model to explain the elevated risk of cancer among obese patients.

脂肪来源的干细胞在肥胖和癌症的十字路口。
肥胖是公众健康的一个主要问题,与患各种癌症的高风险有关。了解这种关系的基本机制对于有效预防和治疗癌症至关重要。脂肪源性干细胞(ADSCs)是从脂肪组织中提取的间充质干细胞(MSCs)的一个特殊亚型。这些细胞有能力经历谱系特异性分化为脂肪细胞、成骨细胞和软骨细胞。尽管ADSCs具有显著的治疗潜力,但现有研究表明,它们可能通过多种途径促进癌症的发生、进展和复发,包括促进肿瘤细胞增殖、上皮-间质转化(EMT)、血管生成、癌症干细胞(CSCs)的形成、免疫逃避和对治疗的抵抗。与正常人相比,肥胖个体的脂肪组织中含有丰富的ADSCs,这突出了ADSCs在肥胖和癌症之间的联系中可能发挥的作用。在这篇综述中,我们探讨了ADSCs在癌症发生、促进和进展中的作用,并提出了一个假设模型来解释肥胖患者癌症风险的升高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Stem Cell Reviews and Reports
Stem Cell Reviews and Reports 医学-细胞生物学
CiteScore
9.30
自引率
4.20%
发文量
0
审稿时长
3 months
期刊介绍: The purpose of Stem Cell Reviews and Reports is to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal will consider for publication: i) solicited or unsolicited reviews of topical areas of stem cell biology that highlight, critique and synthesize recent important findings in the field. ii) full length and short reports presenting original experimental work. iii) translational stem cell studies describing results of clinical trials using stem cells as therapeutics. iv) papers focused on diseases of stem cells. v) hypothesis and commentary articles as opinion-based pieces in which authors can propose a new theory, interpretation of a controversial area in stem cell biology, or a stem cell biology question or paradigm. These articles contain more speculation than reviews, but they should be based on solid rationale. vi) protocols as peer-reviewed procedures that provide step-by-step descriptions, outlined in sufficient detail, so that both experts and novices can apply them to their own research. vii) letters to the editor and correspondence. In order to facilitate this exchange of scientific information and exciting novel ideas, the journal has created five thematic sections, focusing on: i) the role of adult stem cells in tissue regeneration; ii) progress in research on induced pluripotent stem cells, embryonic stem cells and mechanism governing embryogenesis and tissue development; iii) the role of microenvironment and extracellular microvesicles in directing the fate of stem cells; iv) mechanisms of stem cell trafficking, stem cell mobilization and homing with special emphasis on hematopoiesis; v) the role of stem cells in aging processes and cancerogenesis.
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