Characteristics of the gut microbiota in patients with advanced non-small cell lung cancer who responded to immune checkpoint inhibitors.

IF 3.8 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2025-07-02 DOI:10.1038/s41598-025-08049-4

Hideyuki Komatsu, Takuya Sugimoto, Yuzuru Ogata, Takahito Miura, Masanori Aida, Hiroyuki Nishiyama, Mitsuhisa Kawai, Yukihiro Yano, Masahide Mori, Yoshiyuki Shishido

{"title":"Characteristics of the gut microbiota in patients with advanced non-small cell lung cancer who responded to immune checkpoint inhibitors.","authors":"Hideyuki Komatsu, Takuya Sugimoto, Yuzuru Ogata, Takahito Miura, Masanori Aida, Hiroyuki Nishiyama, Mitsuhisa Kawai, Yukihiro Yano, Masahide Mori, Yoshiyuki Shishido","doi":"10.1038/s41598-025-08049-4","DOIUrl":null,"url":null,"abstract":"<p><p>Despite the introduction of immune checkpoint inhibitors (ICIs) in the treatment of lung cancer, the number of deaths from lung cancer remains high, and further improvements in response rates are necessary. Recently, the gut microbiota has been reported to be involved in the therapeutic effects of ICIs; however, only a few studies have examined patients with lung cancer in this context. In the current study, we aimed to explore the association between the gut microbiota before therapy and the efficacy of ICIs in patients with advanced non-small cell lung cancer (NSCLC). The a-diversity of the intestinal microbiota in patients who responded to ICI treatment (responders) was significantly higher than that in those who did not respond to ICIs (non-responders). Additionally, the abundance of Bifidobacteriaceae was significantly higher in the responders than in the non-responders. Furthermore, patients with a high abundance of Bifidobacteriaceae had significantly longer overall survival than those with a low abundance. Counts of Levilactobacillus brevis were significantly higher in responders than in non-responders. Our findings suggest that a higher diversity of the gut microbiota and an abundance of Bifidobacterium and/or L. brevis are distinctive features of the microbiota in patients with NSCLC who respond to ICI treatment.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"23398"},"PeriodicalIF":3.8000,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scientific Reports","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1038/s41598-025-08049-4","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Despite the introduction of immune checkpoint inhibitors (ICIs) in the treatment of lung cancer, the number of deaths from lung cancer remains high, and further improvements in response rates are necessary. Recently, the gut microbiota has been reported to be involved in the therapeutic effects of ICIs; however, only a few studies have examined patients with lung cancer in this context. In the current study, we aimed to explore the association between the gut microbiota before therapy and the efficacy of ICIs in patients with advanced non-small cell lung cancer (NSCLC). The a-diversity of the intestinal microbiota in patients who responded to ICI treatment (responders) was significantly higher than that in those who did not respond to ICIs (non-responders). Additionally, the abundance of Bifidobacteriaceae was significantly higher in the responders than in the non-responders. Furthermore, patients with a high abundance of Bifidobacteriaceae had significantly longer overall survival than those with a low abundance. Counts of Levilactobacillus brevis were significantly higher in responders than in non-responders. Our findings suggest that a higher diversity of the gut microbiota and an abundance of Bifidobacterium and/or L. brevis are distinctive features of the microbiota in patients with NSCLC who respond to ICI treatment.

查看原文本刊更多论文

对免疫检查点抑制剂有反应的晚期非小细胞肺癌患者的肠道微生物群特征

尽管在肺癌治疗中引入了免疫检查点抑制剂（ICIs），但肺癌死亡人数仍然很高，需要进一步提高反应率。最近，肠道微生物群被报道参与了ICIs的治疗效果；然而，只有少数研究在这种情况下检查了肺癌患者。在本研究中，我们旨在探讨晚期非小细胞肺癌（NSCLC）患者治疗前肠道微生物群与ICIs疗效之间的关系。对ICI治疗有反应的患者（应答者）肠道微生物群的a-多样性显著高于对ICI治疗无反应的患者（无应答者）。此外，应答者中双歧杆菌科的丰度显著高于无应答者。此外，双歧杆菌科高丰度患者的总生存期明显长于低丰度患者。应答者的短乳杆菌计数明显高于无应答者。我们的研究结果表明，肠道微生物群的多样性和双歧杆菌和/或短乳杆菌的丰度是对ICI治疗有反应的非小细胞肺癌患者微生物群的显著特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

期刊介绍： We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.