Effect of Periodontal Treatment on Metabolic Syndrome Parameters: A Systematic Review.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-07-02 DOI:10.1111/odi.70018

Anna Simonelli, Filippo Citterio, Fabio Falcone, Francesco D'Aiuto, Nicola Marco Sforza, Salvatore Corrao, Giorgio Sesti, Leonardo Trombelli

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引用次数: 0

Abstract

Aim: To evaluate the effects of periodontal treatment on metabolic syndrome (MS) parameters and systemic inflammatory biomarker levels in patients affected by both MS and periodontitis.

Methods: A systematic search was conducted to identify randomized controlled trials (RCTs) with a follow-up ≥ 1 month comparing a more intense periodontal treatment (test intervention) to either a less intense or no periodontal treatment (control intervention). MS parameters such as triglycerides (TG), high-density lipoprotein cholesterol (HDL), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), and systemic inflammatory biomarkers (i.e., C-reactive protein, CRP) were analyzed. Random-effects meta-regression analyses were conducted at 3- and 6-month follow-ups.

Results: Four RCTs were included. Test intervention resulted in a statistically significant greater SBP reduction at 3 (WMD 1.48) and 6 (WMD 1.88) months compared to control group. A statistically significant difference between groups was observed for FBG at 6 months after treatment, favoring test intervention (WMD 0.61). No differences were observed for the other MS parameters and for CRP at both 3- and 6-month follow-up.

Conclusions: Periodontal treatment seems to have beneficial effects on SBP and FBG in patients with MS and periodontitis at 3-6-month follow-ups.

Trial registration: This systematic review was registered under the protocol registration number CRD42024499854/PROSPERO.

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牙周治疗对代谢综合征参数的影响：系统综述。

目的：探讨牙周治疗对多发性硬化合并牙周炎患者代谢综合征（MS）参数和全身炎症生物标志物水平的影响。方法：进行系统检索，以确定随访≥1个月的随机对照试验（rct），比较高强度牙周治疗（试验干预）与低强度牙周治疗或不进行牙周治疗（对照干预）。分析MS参数，如甘油三酯（TG）、高密度脂蛋白胆固醇（HDL）、空腹血糖（FBG）、糖化血红蛋白（HbA1c）、收缩压（SBP）、舒张压（DBP）、腰围（WC）和全身炎症生物标志物（即c反应蛋白，CRP）。在随访3个月和6个月时进行随机效应meta回归分析。结果：纳入4项随机对照试验。与对照组相比，试验干预导致在3个月（WMD 1.48）和6个月（WMD 1.88）时收缩压降低具有统计学意义。治疗后6个月，两组间FBG差异有统计学意义，有利于试验干预（WMD为0.61）。在3个月和6个月的随访中，其他MS参数和CRP没有观察到差异。结论：在3-6个月的随访中，牙周治疗似乎对MS合并牙周炎患者的收缩压和空腹血糖有有益的影响。试验注册：本系统评价注册方案注册号为CRD42024499854/PROSPERO。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.