Spray drying strategies for the construction of drug-loaded particles: Insights into design principles and pharmaceutical applications

IF 5.2 2区医学 Q1 PHARMACOLOGY & PHARMACY

International Journal of Pharmaceutics Pub Date : 2025-06-30 DOI:10.1016/j.ijpharm.2025.125917

Na Chen , Siqi Huang , Ting Nie, Liang Luo, Tianqi Chen, Kexian Chen, Zeneng Cheng, Wenjie Liu

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Abstract

The design and preparation of particulate drug delivery systems are crucial for enhancing drug efficacy and reducing adverse effects. Spray drying has emerged as a versatile technique for tailoring the particle size, morphology, encapsulation efficiency and release kinetics of drug-loaded particles. This review provides a comprehensive overview of spray drying processes used in the design and fabrication of particulate drug delivery systems. It offers an in-depth analysis of spray drying for modulating the physicochemical properties and performance of drug-loaded particles, as well as its updated applications in various pharmaceutical formulations. Furthermore, the review discusses the different processing parameters of this technique and their effects on drug-loaded particles properties, along with emerging applications in the delivery of biologics and advancements in equipment technology. The objective of this review is to provide researchers with a valuable resource and guide for the recent development and evaluation of spray dried drug-loaded particles.

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喷雾干燥策略的建设载药颗粒：洞察设计原则和制药应用。

颗粒给药系统的设计和制备对于提高药物疗效和减少不良反应至关重要。喷雾干燥已成为一种通用的技术，用于调整颗粒大小，形态，包封效率和药物负载颗粒的释放动力学。这篇综述提供了用于设计和制造颗粒药物输送系统的喷雾干燥过程的全面概述。它提供了一个深入的分析喷雾干燥调节的物理化学性质和载药颗粒的性能，以及其在各种药物配方的最新应用。此外，本文还讨论了该技术的不同处理参数及其对载药颗粒特性的影响，以及在生物制剂输送中的新兴应用和设备技术的进步。本文综述的目的是为喷雾干燥载药颗粒的开发和评价提供有价值的资源和指导。

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来源期刊

International Journal of Pharmaceutics 医学-药学

CiteScore

10.70

自引率

8.60%

发文量

951

审稿时长

72 days

期刊介绍： The International Journal of Pharmaceutics is the third most cited journal in the "Pharmacy & Pharmacology" category out of 366 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.