Zihe Huo, Corinne Légeret, Stefan G Holland-Cunz, Stephanie J Gros
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引用次数: 0
Abstract
Introduction: Despite all precautions, central line-associated bloodstream infections (CLABSI) are inevitable, especially in children. Different treatment strategies exist for those situations. This study aims to compare the different treatment strategies.
Methods: In this study, central venous catheters (CVC, Broviac single lumen) were contaminated with E. coli in vitro. Different treatments (70% ethanol, ceftriaxone, TauroLock) were applied, and the effect was measured by isothermal microcalorimetry.
Results: A rapid decrease in heat release corresponds to a rapid decrease in the number of living bacteria. Ceftriaxone had the quickest effect followed by ethanol in combination with ceftriaxone, ethanol, and TauroLock.
Discussion: Antibiotics must be based on patient risk factors, the severity of infection, and local resistance pattern; therefore, it is difficult to publish general guidelines applying to all children. In this in vitro study, ceftriaxone demonstrated the most the highest efficacy on the bacteria. Taurolidine locks are recommended for preventing CLABSI, but no data are available in regards using it for treatment. In this setting, it was efficient, as was ethanol. However, the bacteria used in this study, have not been exposed to antibiotics before-this is most likely in contrast to patients, who have a central venous catheter.
Conclusion: Under in vitro conditions, systemic ceftriaxone is the most efficient and fastest treatment for an E. coli-infected CVC. Elimination of bacteria was also reached with 70% ethanol and TauroLock, but it needed more time.
期刊介绍:
Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.