Acute effects of two different combined exercise modalities on executive function and circulating neurotrophic factors in young healthy adults.

IF 2.8 3区医学 Q2 PHYSIOLOGY

European Journal of Applied Physiology Pub Date : 2025-07-03 DOI:10.1007/s00421-025-05877-0

Yi-Hung Liao, Toby Mündel, Ying-Chu Chen, Shiow-Chwen Tsai, Kuo-Cheng Wu, Mu-Tsung Chen, Li-Chen Lee, Chih-Peng Su, Yu-Kai Chang, Chung-Yu Chen

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引用次数: 0

Abstract

Purposes: This study investigated the effects of two different combined exercise modalities on executive function in healthy adults and observed the associations of potential biomarkers (i.e., brain-derived neurotrophic factor, BDNF; human growth hormone, HGH; insulin-like growth factor-1, IGF-1; and cortisol) on cognitive performance.

Methods: Twelve young healthy male adults were recruited and assigned to the following three experimental interventions in a randomized crossover manner: sitting control (SC), resistance exercise plus continuous aerobic exercise (RA) and resistance exercise plus intermittent aerobic exercise (RI). Stroop Color and Word Test (SCWT) and blood collection were conducted before and immediately after each intervention.

Results: The results showed that both acute combined exercise trials significantly reduced SCWT-incongruent response time compared to the SC trial (RA: p = .015, RI: p = .014). The serum BDNF and HGH levels were significantly increased in both RA (BDNF: p < .0001, HGH: p = .004) and RI (BDNF: p = .013, HGH: p = .007) trials, and the serum IGF-1 level was significantly increased in the RI trial (p = .008). The changes in SCWT-incongruent response time were significantly associated with the changes in blood lactate (r = - 0.622, p < .0001) and RPE (r = - 0.364, p = .029) following the interventions.

Conclusion: Our findings indicate the beneficial effects of two different combined exercise modalities on executive function in these young healthy males that could be related to an increase in brain energy supply and arousal status.

Irb registration number: IRB-2021-011.

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两种不同的联合运动方式对年轻健康成人执行功能和循环神经营养因子的急性影响

目的：本研究探讨了两种不同的联合运动方式对健康成人执行功能的影响，并观察了潜在生物标志物(即脑源性神经营养因子，BDNF；人生长激素；胰岛素样生长因子-1；皮质醇)对认知表现的影响。方法：招募12名年轻健康男性成人，采用随机交叉方式进行以下三种实验干预：静坐控制（SC）、阻力运动加持续有氧运动（RA）和阻力运动加间歇性有氧运动（RI）。在每次干预前和干预后立即进行Stroop Color and Word Test （SCWT）和采血。结果：结果表明，与SC试验相比，两种急性联合运动试验显著减少了scwt不一致反应时间(RA: p =。015, RI: p = 0.014)。两组RA患者血清BDNF和HGH水平均显著升高（BDNF: p）。结论：我们的研究结果表明，两种不同的联合运动方式对这些年轻健康男性执行功能的有益影响可能与大脑能量供应和觉醒状态的增加有关。Irb注册号：Irb -2021-011。

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来源期刊

European Journal of Applied Physiology 医学-生理学

CiteScore

6.00

自引率

6.70%

发文量

227

审稿时长

3 months

期刊介绍： The European Journal of Applied Physiology (EJAP) aims to promote mechanistic advances in human integrative and translational physiology. Physiology is viewed broadly, having overlapping context with related disciplines such as biomechanics, biochemistry, endocrinology, ergonomics, immunology, motor control, and nutrition. EJAP welcomes studies dealing with physical exercise, training and performance. Studies addressing physiological mechanisms are preferred over descriptive studies. Papers dealing with animal models or pathophysiological conditions are not excluded from consideration, but must be clearly relevant to human physiology.