Marianna Cortese, Alberto Ascherio, Kjetil Bjornevik
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引用次数: 0
Abstract
Although the role of Epstein-Barr virus (EBV) in autoimmunity is biologically plausible and evidence of altered immune responses to EBV is abundant in several autoimmune diseases, inference on causality requires the determination that disease risk is higher in individuals infected with EBV than in those uninfected and that in the latter it increases following EBV infection. This determination has so far been obtained compellingly for multiple sclerosis (MS) and, to some extent, for systemic lupus erythematosus (SLE). In contrast, evidence is either lacking or not supportive for other autoimmune conditions. In this chapter, we present the main epidemiological findings that justify these conclusions and their implications for prevention and treatment.
期刊介绍：
The review series Current Topics in Microbiology and Immunology provides a synthesis of the latest research findings in the areas of molecular immunology, bacteriology and virology. Each timely volume contains a wealth of information on the featured subject. This review series is designed to provide access to up-to-date, often previously unpublished information.
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