{"title":"Role of New Biomarkers in the Early Diagnosis of Gestational Diabetes: A Mini Review.","authors":"Zehra İncedal Sonkaya","doi":"10.2174/0115680266361462250618084953","DOIUrl":null,"url":null,"abstract":"<p><p>Gestational diabetes (GDM) has become a major public health problem in recent years and is one of the most debated topics in women's health. GDM is associated with serious health consequences for both the mother and the child in the short and long term. The prevalence of GDM varies between 0.6% and 20% (depending on the detection method, gestational age, and the population studied). Genetic, nutritional, epigenetic, immunological, and hormonal components have been identified in its pathophysiology. Today, the importance of identifying a biomarker to detect GDM from the beginning of pregnancy in women at high risk of developing GDM is frequently emphasized. In recent years, adipokines and cytokines have been reported to play important roles in the metabolic changes underlying GDM. The purpose of this study was to reveal the potential and importance of the recently identified chemerin, omentin-1, resistin, visfatin, and asprosin peptides with different mechanisms of action in the pathogenesis of GDM.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266361462250618084953","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Gestational diabetes (GDM) has become a major public health problem in recent years and is one of the most debated topics in women's health. GDM is associated with serious health consequences for both the mother and the child in the short and long term. The prevalence of GDM varies between 0.6% and 20% (depending on the detection method, gestational age, and the population studied). Genetic, nutritional, epigenetic, immunological, and hormonal components have been identified in its pathophysiology. Today, the importance of identifying a biomarker to detect GDM from the beginning of pregnancy in women at high risk of developing GDM is frequently emphasized. In recent years, adipokines and cytokines have been reported to play important roles in the metabolic changes underlying GDM. The purpose of this study was to reveal the potential and importance of the recently identified chemerin, omentin-1, resistin, visfatin, and asprosin peptides with different mechanisms of action in the pathogenesis of GDM.
期刊介绍：
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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