{"title":"Brown tumors of both jaws as the initial manifestation of a case of parathyroid carcinoma: a case with a 2-year follow-up.","authors":"Najmeh Movahhedian, Roya Khorrami, Farhad Ghorbani, Razieh Zare","doi":"10.1186/s12903-025-06370-y","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Brown tumors are non-neoplastic giant cell lesions resulting from imbalanced bone metabolism associated with hyperparathyroidism. Although these tumors are infrequently found in the jaw bones, their presence can mimic other bony lesions, making differential diagnosis essential for effective treatment planning.</p><p><strong>Case presentation: </strong>Here, we present a rare case of simultaneous involvement of both jaws by brown tumors in a 37-year-old woman. A comprehensive diagnostic approach including cone beam computed tomographic examination of the jaws, blood biochemistry, scintigraphy (technetium 99 m sestamibi), and biopsy facilitated the identification of underlying parathyroid carcinoma. Notably, the patient experienced spontaneous healing of the extensive brown tumors following endocrine treatment, underscoring the potential for recovery in such cases.</p><p><strong>Conclusion: </strong>This case highlights the essential collaboration between dental and medical professionals in diagnosing complex systemic diseases with oral manifestations, underscoring the dentist's critical role in early detection and improved patient outcomes.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"979"},"PeriodicalIF":2.6000,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Oral Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12903-025-06370-y","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Brown tumors are non-neoplastic giant cell lesions resulting from imbalanced bone metabolism associated with hyperparathyroidism. Although these tumors are infrequently found in the jaw bones, their presence can mimic other bony lesions, making differential diagnosis essential for effective treatment planning.
Case presentation: Here, we present a rare case of simultaneous involvement of both jaws by brown tumors in a 37-year-old woman. A comprehensive diagnostic approach including cone beam computed tomographic examination of the jaws, blood biochemistry, scintigraphy (technetium 99 m sestamibi), and biopsy facilitated the identification of underlying parathyroid carcinoma. Notably, the patient experienced spontaneous healing of the extensive brown tumors following endocrine treatment, underscoring the potential for recovery in such cases.
Conclusion: This case highlights the essential collaboration between dental and medical professionals in diagnosing complex systemic diseases with oral manifestations, underscoring the dentist's critical role in early detection and improved patient outcomes.
背景:棕色肿瘤是由甲状旁腺功能亢进引起的骨代谢不平衡引起的非肿瘤性巨细胞病变。虽然这些肿瘤很少在颌骨中发现,但它们的存在可以模仿其他骨骼病变,因此鉴别诊断对于有效的治疗计划至关重要。病例介绍:在这里,我们提出一个罕见的病例,同时涉及双颌棕色肿瘤在一个37岁的妇女。综合诊断方法包括颌骨锥束计算机断层扫描检查、血液生化、闪烁成像(锝99 m sestamibi)和活检,有助于识别潜在的甲状旁腺癌。值得注意的是,在内分泌治疗后,患者经历了广泛的棕色肿瘤的自发愈合,强调了在这种情况下恢复的潜力。结论:本病例强调了牙科和医学专业人员在诊断具有口腔表现的复杂全身性疾病时的必要合作,强调了牙医在早期发现和改善患者预后方面的关键作用。
期刊介绍:
BMC Oral Health is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the mouth, teeth and gums, as well as related molecular genetics, pathophysiology, and epidemiology.