Ceramide homeostasis in hepatic lipid droplets.

IF 4.3 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Leobarda Robles-Martinez, Kylie H Morin, Mariana Nikolova-Karakashian
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引用次数: 0

Abstract

Almost all eukaryotic cells have the capacity to form lipid droplets (LDs) in conditions of excess energy. Traditionally thought to be just inert fat reservoirs, LDs have recently emerged as important metabolic regulators of cellular stress response that buffer excess free fats and protect cells from lipotoxicity. Ceramide is a bioactive lipid that accumulates in metabolic tissues during fat oversupply. Emerging evidence suggests that sphingolipids and sphingolipid-metabolizing enzymes are found in the LDs and affect LD biogenesis and functions. This article aims to summarize the evidence, delineate some plausible functions of ceramide in hepatic LD biogenesis, and illustrate some of the challenges in this novel field of research. We focus on the biogenesis of LDs in hepatocytes, the parenchymal cells of the liver, because non-alcoholic fatty liver disease is the quintessential manifestation of metabolic stress caused by fat oversupply.

肝脂滴中的神经酰胺稳态。
几乎所有的真核细胞都有能力在能量过剩的情况下形成脂滴(ld)。传统上认为lld只是惰性脂肪储存库,最近出现了作为细胞应激反应的重要代谢调节剂,缓冲多余的游离脂肪并保护细胞免受脂肪毒性。神经酰胺是一种生物活性脂质,在脂肪供过于求时在代谢组织中积累。越来越多的证据表明,鞘脂和鞘脂代谢酶存在于LD中,并影响LD的生物发生和功能。本文旨在总结证据,描述神经酰胺在肝脏LD生物发生中的一些可能的功能,并说明这一新兴研究领域的一些挑战。我们关注肝细胞(肝脏实质细胞)中ld的生物发生,因为非酒精性脂肪性肝病是由脂肪供过于求引起的代谢应激的典型表现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biochemical Society transactions
Biochemical Society transactions 生物-生化与分子生物学
CiteScore
7.80
自引率
0.00%
发文量
351
审稿时长
3-6 weeks
期刊介绍: Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.
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