Reimagining drug nanocarriers: clinical realities and smarter strategies for targeted drug delivery.

IF 12.2 2区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Andrew George Baker, Ljiljana Fruk
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引用次数: 0

Abstract

Recent advances in nanomedicine have significantly improved the delivery of small molecule therapies and biologics for cancer treatment, gene therapy, and vaccines, leading to better patient outcomes and improved standard of care. Yet, despite the promise of targeted drug delivery, clinical trials of targeted nanoparticle-based systems have frequently underperformed. In this opinion piece, we explore the persistent obstacles facing nanomedicine, analyse the shortcomings of targeted strategies, and propose a path forward. We argue that progress will require a re-examination of nanoparticle pharmacokinetics, optimisation of dosing regimens, and solutions to antigen depletion. These steps are critical for realising the full potential of nanomedicine.

重新构想药物纳米载体:靶向药物递送的临床现实和更聪明的策略。
纳米医学的最新进展显著改善了用于癌症治疗、基因治疗和疫苗的小分子疗法和生物制剂的递送,从而改善了患者的治疗效果,提高了护理标准。然而,尽管靶向药物递送有望实现,基于靶向纳米颗粒的系统的临床试验却经常表现不佳。在这篇观点文章中,我们探讨了纳米医学面临的持续障碍,分析了有针对性的战略的缺点,并提出了前进的道路。我们认为,进展将需要重新检查纳米颗粒的药代动力学,优化给药方案和抗原消耗的解决方案。这些步骤对于实现纳米医学的全部潜力至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Materials Horizons
Materials Horizons CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
18.90
自引率
2.30%
发文量
306
审稿时长
1.3 months
期刊介绍: Materials Horizons is a leading journal in materials science that focuses on publishing exceptionally high-quality and innovative research. The journal prioritizes original research that introduces new concepts or ways of thinking, rather than solely reporting technological advancements. However, groundbreaking articles featuring record-breaking material performance may also be published. To be considered for publication, the work must be of significant interest to our community-spanning readership. Starting from 2021, all articles published in Materials Horizons will be indexed in MEDLINE©. The journal publishes various types of articles, including Communications, Reviews, Opinion pieces, Focus articles, and Comments. It serves as a core journal for researchers from academia, government, and industry across all areas of materials research. Materials Horizons is a Transformative Journal and compliant with Plan S. It has an impact factor of 13.3 and is indexed in MEDLINE.
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