Synthesis, Characterization, and Degradation on the Quasi-Alternating Polyester Amides Derived from ε-Caprolactone, Diamine, and Diacid.

IF 5.5 2区 化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Kan Cheng, Tao Liu, Simeng Gao, Fangfang Niu, Xueli Wang, Jianyong Yu, Yanping Wang, Shuohan Huang, Yong He
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引用次数: 0

Abstract

Poly(ε-caprolactone) (PCL) has been widely studied due to its excellent biodegradability and biocompatibility. However, its low melting temperature (∼60 °C) and limited tensile strength (∼10 MPa) restrict its application in high-performance or thermally demanding environments. To overcome these limitations, we developed a novel two-step melt polycondensation strategy to synthesize quasi-alternating poly(ester amide)s (PEAs) by incorporating diamide diols derived from ε-caprolactone. This synthetic approach enables precise control over the polymer microstructure, leading to PEAs with tunable crystallinity, enhanced chain regularity, and improved segmental interactions. The successful synthesis of PEAs was confirmed using nuclear magnetic resonance and infrared spectroscopy. The results demonstrate that PEAs possess adjustable melting temperatures (Tm = 134-139 °C), moderate crystallinity (Xc = 17-35%), excellent transparency (T > 85%), tensile strength (15-18 MPa), and high elongation at break (ε = 68-800%). This work offers a promising route toward high-performance, sustainable materials for packaging and biomedical applications.

ε-己内酯、二胺、二酸类准交替聚酯酰胺的合成、表征及降解研究。
聚ε-己内酯(PCL)因其良好的生物可降解性和生物相容性而受到广泛的研究。然而,其低熔融温度(~ 60°C)和有限的抗拉强度(~ 10 MPa)限制了其在高性能或热要求苛刻的环境中的应用。为了克服这些限制,我们开发了一种新的两步熔融缩聚策略,通过加入从ε-己内酯衍生的二胺二醇来合成准交替聚(酯酰胺)s(豌豆)。这种合成方法可以精确控制聚合物的微观结构,从而使豌豆具有可调的结晶度、增强的链规则性和改善的片段相互作用。利用核磁共振和红外光谱技术证实了豌豆的成功合成。结果表明,豌豆具有可调的熔融温度(Tm = 134-139℃),中等结晶度(Xc = 17-35%),优异的透明度(t> 85%),抗拉强度(15-18 MPa)和高断裂伸长率(ε = 68-800%)。这项工作为包装和生物医学应用的高性能、可持续材料提供了一条有前途的途径。
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来源期刊
Biomacromolecules
Biomacromolecules 化学-高分子科学
CiteScore
10.60
自引率
4.80%
发文量
417
审稿时长
1.6 months
期刊介绍: Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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