Kan Cheng, Tao Liu, Simeng Gao, Fangfang Niu, Xueli Wang, Jianyong Yu, Yanping Wang, Shuohan Huang, Yong He
{"title":"Synthesis, Characterization, and Degradation on the Quasi-Alternating Polyester Amides Derived from ε-Caprolactone, Diamine, and Diacid.","authors":"Kan Cheng, Tao Liu, Simeng Gao, Fangfang Niu, Xueli Wang, Jianyong Yu, Yanping Wang, Shuohan Huang, Yong He","doi":"10.1021/acs.biomac.5c00441","DOIUrl":null,"url":null,"abstract":"<p><p>Poly(ε-caprolactone) (PCL) has been widely studied due to its excellent biodegradability and biocompatibility. However, its low melting temperature (∼60 °C) and limited tensile strength (∼10 MPa) restrict its application in high-performance or thermally demanding environments. To overcome these limitations, we developed a novel two-step melt polycondensation strategy to synthesize quasi-alternating poly(ester amide)s (PEAs) by incorporating diamide diols derived from ε-caprolactone. This synthetic approach enables precise control over the polymer microstructure, leading to PEAs with tunable crystallinity, enhanced chain regularity, and improved segmental interactions. The successful synthesis of PEAs was confirmed using nuclear magnetic resonance and infrared spectroscopy. The results demonstrate that PEAs possess adjustable melting temperatures (<i>T</i><sub>m</sub> = 134-139 °C), moderate crystallinity (<i>X</i><sub>c</sub> = 17-35%), excellent transparency (<i>T</i> > 85%), tensile strength (15-18 MPa), and high elongation at break (ε = 68-800%). This work offers a promising route toward high-performance, sustainable materials for packaging and biomedical applications.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomacromolecules","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.biomac.5c00441","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Poly(ε-caprolactone) (PCL) has been widely studied due to its excellent biodegradability and biocompatibility. However, its low melting temperature (∼60 °C) and limited tensile strength (∼10 MPa) restrict its application in high-performance or thermally demanding environments. To overcome these limitations, we developed a novel two-step melt polycondensation strategy to synthesize quasi-alternating poly(ester amide)s (PEAs) by incorporating diamide diols derived from ε-caprolactone. This synthetic approach enables precise control over the polymer microstructure, leading to PEAs with tunable crystallinity, enhanced chain regularity, and improved segmental interactions. The successful synthesis of PEAs was confirmed using nuclear magnetic resonance and infrared spectroscopy. The results demonstrate that PEAs possess adjustable melting temperatures (Tm = 134-139 °C), moderate crystallinity (Xc = 17-35%), excellent transparency (T > 85%), tensile strength (15-18 MPa), and high elongation at break (ε = 68-800%). This work offers a promising route toward high-performance, sustainable materials for packaging and biomedical applications.
期刊介绍:
Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine.
Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.