{"title":"Fabrication of pH-sensitive bacterial cellulose/carboxymethyl cellulose hybrid hydrogel beads in agitated culture for oral drug delivery","authors":"Ali Sattari, Ali Basirattalab, Iran Alemzadeh","doi":"10.1002/cjce.25609","DOIUrl":null,"url":null,"abstract":"<p>Bacterial cellulose (BC), a biopolymer with unique properties, has been employed in numerous biomedical applications. Carboxymethyl cellulose was introduced to the agitated culture of <i>Gluconacetobacter xylinus</i> to produce pH-responsive BC hydrogel beads. It was shown by x-ray diffraction (XRD) analysis that adding carboxymethyl cellulose to the agitated culture increased the crystallinity of the hydrogel beads. Scanning electron microscopy exhibited the 3-D porous structure of microfibrils and the reverse effect of adding carboxymethyl cellulose on the hydrogels' porosity. The hydrogels were loaded with ibuprofen sodium salt (IbuNa), and their release and swelling studies were conducted in the simulated gastric and simulated intestinal fluids. It was observed that by increasing the amount of carboxymethyl cellulose in the culture medium, the pH responsivity of the beads was increased. Thus, this study shows the potential of the BC/CMC system as an oral drug delivery system.</p>","PeriodicalId":9400,"journal":{"name":"Canadian Journal of Chemical Engineering","volume":"103 8","pages":"3521-3530"},"PeriodicalIF":1.6000,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian Journal of Chemical Engineering","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cjce.25609","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Bacterial cellulose (BC), a biopolymer with unique properties, has been employed in numerous biomedical applications. Carboxymethyl cellulose was introduced to the agitated culture of Gluconacetobacter xylinus to produce pH-responsive BC hydrogel beads. It was shown by x-ray diffraction (XRD) analysis that adding carboxymethyl cellulose to the agitated culture increased the crystallinity of the hydrogel beads. Scanning electron microscopy exhibited the 3-D porous structure of microfibrils and the reverse effect of adding carboxymethyl cellulose on the hydrogels' porosity. The hydrogels were loaded with ibuprofen sodium salt (IbuNa), and their release and swelling studies were conducted in the simulated gastric and simulated intestinal fluids. It was observed that by increasing the amount of carboxymethyl cellulose in the culture medium, the pH responsivity of the beads was increased. Thus, this study shows the potential of the BC/CMC system as an oral drug delivery system.
期刊介绍:
The Canadian Journal of Chemical Engineering (CJChE) publishes original research articles, new theoretical interpretation or experimental findings and critical reviews in the science or industrial practice of chemical and biochemical processes. Preference is given to papers having a clearly indicated scope and applicability in any of the following areas: Fluid mechanics, heat and mass transfer, multiphase flows, separations processes, thermodynamics, process systems engineering, reactors and reaction kinetics, catalysis, interfacial phenomena, electrochemical phenomena, bioengineering, minerals processing and natural products and environmental and energy engineering. Papers that merely describe or present a conventional or routine analysis of existing processes will not be considered.