Fabrication of pH-sensitive bacterial cellulose/carboxymethyl cellulose hybrid hydrogel beads in agitated culture for oral drug delivery

IF 1.6 4区 工程技术 Q3 ENGINEERING, CHEMICAL
Ali Sattari, Ali Basirattalab, Iran Alemzadeh
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引用次数: 0

Abstract

Bacterial cellulose (BC), a biopolymer with unique properties, has been employed in numerous biomedical applications. Carboxymethyl cellulose was introduced to the agitated culture of Gluconacetobacter xylinus to produce pH-responsive BC hydrogel beads. It was shown by x-ray diffraction (XRD) analysis that adding carboxymethyl cellulose to the agitated culture increased the crystallinity of the hydrogel beads. Scanning electron microscopy exhibited the 3-D porous structure of microfibrils and the reverse effect of adding carboxymethyl cellulose on the hydrogels' porosity. The hydrogels were loaded with ibuprofen sodium salt (IbuNa), and their release and swelling studies were conducted in the simulated gastric and simulated intestinal fluids. It was observed that by increasing the amount of carboxymethyl cellulose in the culture medium, the pH responsivity of the beads was increased. Thus, this study shows the potential of the BC/CMC system as an oral drug delivery system.

在搅拌培养中制备ph敏感细菌纤维素/羧甲基纤维素混合水凝胶珠用于口服药物递送
细菌纤维素(BC)是一种具有独特性质的生物聚合物,已被广泛应用于生物医学领域。将羧甲基纤维素引入木糖醋杆菌的搅拌培养中,生产ph响应型BC水凝胶珠。x射线衍射(XRD)分析表明,在搅拌培养中加入羧甲基纤维素可以提高水凝胶珠的结晶度。扫描电镜显示了微纤维的三维多孔结构和添加羧甲基纤维素对水凝胶孔隙度的相反影响。将水凝胶装入布洛芬钠盐(IbuNa),并在模拟胃液和模拟肠液中进行释放和肿胀研究。观察到,通过增加培养基中羧甲基纤维素的量,可以提高微球的pH响应性。因此,本研究显示了BC/CMC系统作为口服给药系统的潜力。
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来源期刊
Canadian Journal of Chemical Engineering
Canadian Journal of Chemical Engineering 工程技术-工程:化工
CiteScore
3.60
自引率
14.30%
发文量
448
审稿时长
3.2 months
期刊介绍: The Canadian Journal of Chemical Engineering (CJChE) publishes original research articles, new theoretical interpretation or experimental findings and critical reviews in the science or industrial practice of chemical and biochemical processes. Preference is given to papers having a clearly indicated scope and applicability in any of the following areas: Fluid mechanics, heat and mass transfer, multiphase flows, separations processes, thermodynamics, process systems engineering, reactors and reaction kinetics, catalysis, interfacial phenomena, electrochemical phenomena, bioengineering, minerals processing and natural products and environmental and energy engineering. Papers that merely describe or present a conventional or routine analysis of existing processes will not be considered.
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