Polyvinylpyrrolidone Influences the Sol–Gel Preparation and Heat Generation Ability of Zinc–Cobalt Ferrite Nanoparticles Designed for Hyperthermia

Zaid Mukhtar, Jin Nakamura, Toshiki Miyazaki
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Abstract

Magnetic nanoparticles generate heat when exposed to an alternating magnetic field, making them useful as thermoseeds for efficient hyperthermia treatment of deep-seated cancer inside the body. Among them, the Curie point of zinc–cobalt ferrite can be tuned within the 40°C range by controlling the composition, thereby suppressing excessive temperature increases in the body during treatment. These nanoparticles are also expected to have antibacterial effects. During synthesis, the microstructure and properties can be regulated by adding organic substances. Herein, zinc–cobalt ferrite nanoparticles were synthesized using sol–gel methods with varying amounts of polyvinylpyrrolidone (PVP), and the effects of the synthesis conditions on the microstructure, magnetic properties, and heat generation behavior were investigated. The highest temperature increase of around 60°C was observed for samples prepared with 6 wt% PVP, but it decreased when the concentration was increased to 9 wt%. This was attributed to aggregation and the formation of nonmagnetic compounds.

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聚乙烯吡咯烷酮对热疗用锌钴铁氧体纳米颗粒溶胶-凝胶制备及产热能力的影响
当暴露在交变磁场中时,磁性纳米颗粒会产生热量,这使得它们可以作为热种子,用于对体内深层癌症进行有效的热疗治疗。其中,锌钴铁氧体的居里点可以通过控制成分在40℃范围内调节,从而抑制治疗过程中体内温度的过度升高。这些纳米颗粒也有望具有抗菌作用。在合成过程中,可以通过添加有机物来调节其微观结构和性能。本文采用溶胶-凝胶法制备了不同用量的聚乙烯吡咯烷酮(PVP)纳米锌钴铁氧体,研究了合成条件对纳米锌钴铁氧体微观结构、磁性能和产热行为的影响。PVP浓度为6 wt%时,升温幅度最大,约为60°C,但当PVP浓度增加到9 wt%时,升温幅度减小。这归因于非磁性化合物的聚集和形成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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