Islam Ahmed Abdelmawgood , Mohamed A. Kotb , Hassan Samy Hassan Eltras , Noha A. Mahana , Lamiaa Goda , Ahmed M. Rochdi , Nader Hassan Sayed , Reem H. Elsafoury , Amal M. Saber , Mahmoud Nabil Youssef , Nancy George Waheeb , Hamid Ashry , Bassam W. Ebeed , Mohamed W.A. Al-Rifai , Abeer Mahmoud Badr , Hadeer Hesham Abdelfattah
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引用次数: 0
Abstract
Background
Asthma is a chronic airway disease characterized by immunological dysregulation that causes sustained inflammation, leading to aberrant airway narrowing and mucus production. Isopimpinellin (IP) is a naturally occurring furanocoumarin, generated by an association of coumarin and a furan ring, possessing antifungal, antibacterial, and antioxidant properties; however, its potential in asthma treatment has not been investigated. This study sought to evaluate the anti-inflammatory and antioxidant effects of IP in an ovalbumin (OVA)-induced murine model of asthma.
Methods
Mice were grouped into four groups (n = 8 per group): control, OVA, and IP-treated (35 and 70 mg/kg). At the end of the experiment, lung oxidative stress, inflammation, and histopathological changes were evaluated.
Results
IP treatment significantly ameliorated airway oxidative stress by decreasing the concentration of malondialdehyde (MDA) and increasing the levels of antioxidants, including glutathione (GSH), catalase (CAT), and glutathione peroxidase (GPx); reduced inflammatory cell infiltration; mitigated histological changes; and decreased levels of IL-4, IL-13, and IgE. Additionally, IP prevented NF-κB phosphorylation. This study is the first examination of the anti-asthmatic properties of IP in allergic asthma in murine models.
Conclusion
Our data indicate that IP may function as an anti-asthmatic medication via regulating oxidative stress and inflammation.
期刊介绍:
Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense.
Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as:
-Mechanics of breathing-
Gas exchange and acid-base balance-
Respiration at rest and exercise-
Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen-
Embryonic and adult respiration-
Comparative respiratory physiology.
Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.