Correlación entre biomarcadores de mal pronóstico visual por tomografía de coherencia óptica en edema macular diabético y el nivel de albuminuria en pacientes con enfermedad renal crónica

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-07-01 DOI:10.1016/j.oftal.2025.03.008

S. Menchaca Gutiérrez, L.F. Yañez Ortega, E. Sánchez Hernández

{"title":"Correlación entre biomarcadores de mal pronóstico visual por tomografía de coherencia óptica en edema macular diabético y el nivel de albuminuria en pacientes con enfermedad renal crónica","authors":"S. Menchaca Gutiérrez, L.F. Yañez Ortega, E. Sánchez Hernández","doi":"10.1016/j.oftal.2025.03.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To determine the correlation of poor visual prognosis biomarkers by Optical Coherence Tomography (OCT) in diabetic macular edema with the level of albuminuria in patients with Chronic Kidney Disease.</div></div><div><h3>Design</h3><div>This is a retrospective, observational, cross-sectional, and analytical study</div></div><div><h3>Participants</h3><div>All patients diagnosed with diabetic macular edema who attended the retina department of the Ophthalmology service and met the inclusion criteria between March 2021 and August 2022.</div></div><div><h3>Methods</h3><div>Data gathering was done through medical record reviews and the patients were divided based on 3 categories of albuminuria. OCT images of the affected eye, which was considered to be the one that was eligible for anti- VEGF treatment, were collected and analyzed, and the corresponding subdivision was made depending on the presence of poor visual prognosis OCT biomarkers.</div></div><div><h3>Results</h3><div>Chi-square goodness-of-fit tests were performed to analyze whether the proportion of biomarkers in each albuminuria category is due to chance or is related to each A1-A3 albuminuria level. A direct correlation was found between the absence of integrity in the outer retinal layers and the severity of albuminuria.</div></div><div><h3>Conclusions</h3><div>OCT may serve as a valuable tool for detecting kidney damage by considering the relationship between certain biomarkers and the presence of albuminuria, particularly the disruption of the outer retinal layers, which could serve as an OCT biomarker for advanced kidney disease.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 392-396"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivos De La Sociedad Espanola De Oftalmologia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0365669125000553","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

To determine the correlation of poor visual prognosis biomarkers by Optical Coherence Tomography (OCT) in diabetic macular edema with the level of albuminuria in patients with Chronic Kidney Disease.

Design

This is a retrospective, observational, cross-sectional, and analytical study

Participants

All patients diagnosed with diabetic macular edema who attended the retina department of the Ophthalmology service and met the inclusion criteria between March 2021 and August 2022.

Methods

Data gathering was done through medical record reviews and the patients were divided based on 3 categories of albuminuria. OCT images of the affected eye, which was considered to be the one that was eligible for anti- VEGF treatment, were collected and analyzed, and the corresponding subdivision was made depending on the presence of poor visual prognosis OCT biomarkers.

Results

Chi-square goodness-of-fit tests were performed to analyze whether the proportion of biomarkers in each albuminuria category is due to chance or is related to each A1-A3 albuminuria level. A direct correlation was found between the absence of integrity in the outer retinal layers and the severity of albuminuria.

Conclusions

OCT may serve as a valuable tool for detecting kidney damage by considering the relationship between certain biomarkers and the presence of albuminuria, particularly the disruption of the outer retinal layers, which could serve as an OCT biomarker for advanced kidney disease.

查看原文本刊更多论文

糖尿病黄斑水肿的光学相干断层扫描视力预后差的生物标志物与慢性肾病患者白蛋白尿水平之间的相关性

目的探讨慢性肾病患者糖尿病性黄斑水肿视觉预后不良生物标志物与尿白蛋白水平的相关性。这是一项回顾性、观察性、横断面性和分析性研究。参与者：所有在2021年3月至2022年8月期间在眼科视网膜科就诊并符合纳入标准的诊断为糖尿病性黄斑水肿的患者。方法通过病历回顾收集资料，将患者按蛋白尿的3种类型进行分组。收集和分析被认为符合抗VEGF治疗条件的受累眼OCT图像，并根据视觉预后不良OCT生物标志物的存在进行相应的细分。结果采用双方拟合优度检验分析各蛋白尿类别中生物标志物的比例是偶然还是与各A1-A3蛋白尿水平相关。在视网膜外层完整性的缺失和蛋白尿的严重程度之间发现了直接的相关性。结论考虑到某些生物标志物与蛋白尿的存在之间的关系，soct可能是一种有价值的检测肾脏损害的工具，特别是视网膜外层的破坏，可以作为晚期肾脏疾病的OCT生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Archivos De La Sociedad Espanola De Oftalmologia Medicine-Ophthalmology

CiteScore

1.20

自引率

0.00%

发文量

109

审稿时长

78 days

期刊介绍： La revista Archivos de la Sociedad Española de Oftalmología, editada mensualmente por la propia Sociedad, tiene como objetivo publicar trabajos de investigación básica y clínica como artículos originales; casos clínicos, innovaciones técnicas y correlaciones clinicopatológicas en forma de comunicaciones cortas; editoriales; revisiones; cartas al editor; comentarios de libros; información de eventos; noticias personales y anuncios comerciales, así como trabajos de temas históricos y motivos inconográficos relacionados con la Oftalmología. El título abreviado es Arch Soc Esp Oftalmol, y debe ser utilizado en bibliografías, notas a pie de página y referencias bibliográficas.