Relationship between preoperative nutritional status with postoperative IL-10 and neopterin in gynecologic oncology patients

IF 3.2 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Pub Date : 2025-06-09 DOI:10.1016/j.nut.2025.112873

Fazıl Avcı M.D. , Ahmet Bilgi M.D. , Ayse Gül Kebapcılar M.D. , Mehmet Kulhan M.D. , Fikret Akyürek M.D. , Cetin Celik M.D.

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Abstract

Introduction

We aimed to investigate the relationship between preoperative nutritional status with postoperative interleukin-10 (IL-10) and neopterin in gynecologic oncology cases.

Materials and methods

This prospective study included cases hospitalized in our clinic. Preoperative cases were divided into two groups as low and high risk according to Nutritional risk score (NSR-2002). Demographic and clinical characteristics and questionnaires including the NSR-2002 form were recorded. IL-10 and neopterin levels were analyzed 1 week postoperatively.

Results

Forty-five low-risk and 43 high-risk cases were evaluated. The mean ages of the cases were 56.7 ± 7.8 and 57.2 ± 14.3 years, respectively, and no significant difference was found between them (P = 0.854). There was a statistically significant difference between the two groups in terms of upper arm circumference (P = 0.043), triceps skinfold thickness (P = 0.010), shorter wound healing time (P = 0.009), neopterin (P = 0.037), IL-10 (P = 0.043), preoperative ferritin (P = 0.001), hemoglobulin (P = 0.026), albumin (P = 0.047), postoperative ferritin (P = 0.015), hemoglobulin (P = 0.044), and albumin (P = 0.042) levels in favor of the low-risk group. Among the significant factors, only wound healing time had positive correlation (P = 0.006, r = +0.290).

Conclusions

Nutritional status is closely related to case recovery in the postoperative period. Postoperative changes to high interleukin-10 and neopterin levels in cases with low nutritional index show the importance of nutrition in the postoperative period.

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妇科肿瘤患者术前营养状况与术后IL-10、新蝶呤的关系

目的探讨妇科肿瘤患者术前营养状况与术后白细胞介素-10 （IL-10, neopterin）的关系。材料与方法本前瞻性研究纳入我院住院病例。术前根据营养风险评分（NSR-2002）将患者分为低危和高危两组。记录了人口统计学和临床特征以及包括NSR-2002表格在内的调查问卷。术后1周分析IL-10和neopterin水平。结果低危病例45例，高危病例43例。患者平均年龄分别为56.7±7.8岁和57.2±14.3岁，两组间差异无统计学意义（P = 0.854）。两组在上臂围度（P = 0.043）、肱三头肌皮褶厚度（P = 0.010）、较短的创面愈合时间（P = 0.009）、新蝶蛋白（P = 0.037）、IL-10 （P = 0.043）、术前铁蛋白（P = 0.001）、血红蛋白（P = 0.026）、白蛋白（P = 0.047）、术后铁蛋白（P = 0.015）、血红蛋白（P = 0.044）、白蛋白（P = 0.042）水平上差异均有统计学意义。在显著性因素中，只有创面愈合时间呈正相关（P = 0.006, r = +0.290）。结论营养状况与患者术后恢复密切相关。低营养指数患者术后白细胞介素-10和新蝶素水平增高，说明营养在术后的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition 医学-营养学

CiteScore

7.80

自引率

2.30%

发文量

300

审稿时长

60 days

期刊介绍： Nutrition has an open access mirror journal Nutrition: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Founded by Michael M. Meguid in the early 1980''s, Nutrition presents advances in nutrition research and science, informs its readers on new and advancing technologies and data in clinical nutrition practice, encourages the application of outcomes research and meta-analyses to problems in patient-related nutrition; and seeks to help clarify and set the research, policy and practice agenda for nutrition science to enhance human well-being in the years ahead.