Integrated meta-analysis reveals circulating miRNA panel for hepatocellular carcinoma diagnosis

IF 0.5 Q4 GENETICS & HEREDITY
Isbah Ashfaq , Naz Fatima , Nadeem Sheikh , Asima Tayyeb
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引用次数: 0

Abstract

Objective

HCC is the leading cause of deaths primarily in patients with liver ailment. Considering its incidence rate as global burden, efficacy of multiple drugs have changed the landscape of overall management of this disease. Recently, diagnosis based on non-invasive microRNAs has impacted the clinical outcomes of various cancers. The current study focuses on identifying potential non-invasive biomarkers for the early detection of HCC.

Methods

This research underscores the significance of a unique panel of circulating miRNAs observed at three distinct stages of liver disease: chronic hepatitis, liver cirrhosis, and HCC. The dataset, comprising microarray profiles of circulating miRNAs, was acquired from GEO repository. The DE-miRNAs and their overlapping at different stages of liver diseases were identified. The bioinformatics analyses were performed and statistical analysis was conducted to identify the significant and unique panel of circulating miRNAs.

Results

Altogether, 3 miRNAs such as hsa-miR-1290, hsa-let-7a-5p, and hsa-mir-16-5p were found with AUC ≥0.80 and P-value ≤0.05. Furthermore, pathways enrichment analysis revealed association of genes and signalling pathways.

Conclusion

In conclusion, suggested panel of circulating miRNAs may provide a potential approach for non-invasive diagnosis of HCC. These miRNAs could serve as timely indicators for detecting HCC, thereby offering a promising strategy for the effective management of this condition.
综合荟萃分析显示循环miRNA可用于肝细胞癌的诊断
目的hcc是肝脏疾病患者死亡的主要原因。考虑到其发病率是全球负担,多种药物的疗效已经改变了这种疾病的整体管理格局。近年来,基于非侵入性microrna的诊断已经影响了各种癌症的临床结果。目前的研究重点是确定HCC早期检测的潜在非侵入性生物标志物。该研究强调了在慢性肝炎、肝硬化和HCC这三个不同阶段肝脏疾病中观察到的一组独特的循环mirna的重要性。该数据集包括循环mirna的微阵列谱,从GEO存储库获得。确定了de - mirna及其在肝脏疾病不同阶段的重叠。进行生物信息学分析,并进行统计分析,以确定显著和独特的循环mirna组。结果共检出hsa-miR-1290、hsa-let-7a-5p、hsa-mir-16-5p 3个mirna, AUC≥0.80,p值≤0.05。此外,途径富集分析揭示了基因与信号通路的关联。结论所建议的循环mirna组可能为HCC的无创诊断提供潜在的方法。这些mirna可以作为检测HCC的及时指标,从而为有效治疗HCC提供了有希望的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Human Gene
Human Gene Biochemistry, Genetics and Molecular Biology (General), Genetics
CiteScore
1.60
自引率
0.00%
发文量
0
审稿时长
54 days
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