Diya Flenaugh , Morgan Pride , Evelyn M. Chang , Alex Y. Chang , Lauren Bethea , Antoniette Maldonado-Devincci , Jian Han
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引用次数: 0
Abstract
High-fat diet (HFD) consumption influences the risk of Parkinson’s disease (PD), with effects varying based on exposure duration. This study examined the impact of a short-term, lard-based HFD on motor and anxiety-like behaviors, as well as dopaminergic markers, in a PD mouse model (A53T mice). One-month-old male and female A53T mice were fed either a control (10 % kcal from fat) or an HFD (45 % kcal from fat) diet for three months. Sex-specific differences in weight gain, behavior, and dopaminergic markers were assessed. HFD-fed male mice gained significantly more weight than control males (p < 0.0001),whereas weight gain in females was less affected by diet. No significant dietary effects were observed on motor behaviors or dopaminergic markers, including α-synuclein, dopamine, dopamine receptor D2, dopamine transporter, and vesicular monoamine transporter 2. However, a significant sex effect was found for anxiety-like behavior. Additionally, oxidative stress was elevated in males compared to females and was further exacerbated by HFD in males. These findings suggest that although short-term HFD did not impact motor behavior or dopaminergic markers, male mice were more susceptible to HFD-induced weight gain and oxidative stress than females.
期刊介绍:
Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.