Short-term high-fat diet elevates oxidative stress in male but not female A53T mice without altering striatal dopaminergic markers

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES
Diya Flenaugh , Morgan Pride , Evelyn M. Chang , Alex Y. Chang , Lauren Bethea , Antoniette Maldonado-Devincci , Jian Han
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引用次数: 0

Abstract

High-fat diet (HFD) consumption influences the risk of Parkinson’s disease (PD), with effects varying based on exposure duration. This study examined the impact of a short-term, lard-based HFD on motor and anxiety-like behaviors, as well as dopaminergic markers, in a PD mouse model (A53T mice). One-month-old male and female A53T mice were fed either a control (10 % kcal from fat) or an HFD (45 % kcal from fat) diet for three months. Sex-specific differences in weight gain, behavior, and dopaminergic markers were assessed. HFD-fed male mice gained significantly more weight than control males (p < 0.0001),whereas weight gain in females was less affected by diet. No significant dietary effects were observed on motor behaviors or dopaminergic markers, including α-synuclein, dopamine, dopamine receptor D2, dopamine transporter, and vesicular monoamine transporter 2. However, a significant sex effect was found for anxiety-like behavior. Additionally, oxidative stress was elevated in males compared to females and was further exacerbated by HFD in males. These findings suggest that although short-term HFD did not impact motor behavior or dopaminergic markers, male mice were more susceptible to HFD-induced weight gain and oxidative stress than females.
在不改变纹状体多巴胺能标记物的情况下,短期高脂肪饮食会升高雄性A53T小鼠的氧化应激,而雌性A53T小鼠则不会
高脂肪饮食(HFD)的消费影响帕金森病(PD)的风险,其影响取决于暴露时间的长短。本研究在PD小鼠模型(A53T小鼠)中检测了短期猪油基HFD对运动和焦虑样行为以及多巴胺能标记物的影响。一个月大的雄性和雌性A53T小鼠分别被喂食对照组(10 %卡路里来自脂肪)或HFD(45 %卡路里来自脂肪)饮食三个月。评估了体重增加、行为和多巴胺能标记物的性别差异。饲喂hfd的雄性小鼠体重明显高于对照组(p <; 0.0001),而雌性小鼠体重增加受饮食影响较小。饲料对运动行为和多巴胺能指标(包括α-突触核蛋白、多巴胺、多巴胺受体D2、多巴胺转运蛋白和水泡单胺转运蛋白2)均无显著影响。然而,研究发现,性别对焦虑类行为有显著影响。此外,与女性相比,男性的氧化应激升高,并且男性的HFD进一步加剧了氧化应激。这些发现表明,尽管短期HFD不影响运动行为或多巴胺能标记物,但雄性小鼠比雌性小鼠更容易受到HFD诱导的体重增加和氧化应激的影响。
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来源期刊
Behavioural Brain Research
Behavioural Brain Research 医学-行为科学
CiteScore
5.60
自引率
0.00%
发文量
383
审稿时长
61 days
期刊介绍: Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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