Dyes inspired ratiometric fluorescent sensors for glycosaminoglycans

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2025-07-02 DOI:10.1016/j.dyepig.2025.113000

Shan Li, Haoyuan Deng, Yusheng Fan, Yubin Ding

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Abstract

Glycosaminoglycans are a family of linear polysaccharides with versatile biological activities. Representative examples such as heparin, chondroitin sulfate and hyaluronic acid are widely used in clinics. However, the chemical structure of these compounds is complicated. Analysis of the concentration and purity of a given glycosaminoglycan sample is inconvenient and simple, cheaper methods are required. It is therefore still meaningful to develop reliable and effective analytical tools for sensing of glycosaminoglycans. In this review, we have summarized the recent development in the design of ratiometric fluorescent sensors for glycosaminoglycans. Especially, this review is focussed on sensors which utilize organic dyes as the signal reporters. This is because small dyes exhibit many merits such as readily and controllable synthetic chemistry, low cost, and sensitive response to glycosaminoglycans. The discussion on ratiometric fluorescent sensors for glycosaminoglycans was divided into three subtopics including small organic molecule-based fluorescent sensors, dye-embedded fluorescent polymers and dye-nanomaterial hybrid sensors for glycosaminoglycans. Finally, recognizing the significance of turn-on fluorescence for glycosaminoglycans detection, recent developments in fluorescent turn-on sensors for glycosaminoglycans are discussed with representative examples.

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染料启发的糖胺聚糖比例荧光传感器

糖胺聚糖是一类具有多种生物活性的线性多糖。肝素、硫酸软骨素、透明质酸等代表性药物在临床上应用广泛。然而，这些化合物的化学结构是复杂的。分析给定的糖胺聚糖样品的浓度和纯度是不方便和简单的，需要更便宜的方法。因此，开发可靠、有效的糖胺聚糖检测工具仍具有重要意义。本文综述了近年来糖胺聚糖比例荧光传感器的研究进展。本文特别对利用有机染料作为信号报告器的传感器进行了综述。这是因为小染料具有易于控制合成化学、成本低、对糖胺聚糖反应灵敏等优点。对糖胺聚糖比例荧光传感器的研究分为有机小分子荧光传感器、染料嵌入荧光聚合物和糖胺聚糖染料-纳米杂化传感器三个子主题。最后，认识到开启荧光对糖胺聚糖检测的重要性，并以代表性的例子讨论了糖胺聚糖荧光开启传感器的最新进展。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.