Sonja Ständer, Emma Guttman-Yassky, Gil Yosipovitch, Henning Wiegmann, Dieter Metze, Madeline Kim, Ester Del Duca, Kent Bondensgaard, John F. Paolini, The LOTUS-PN Investigators Group
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引用次数: 0
Abstract
Background and Objectives
Prurigo nodularis (PN) is a severe, intensely pruritic subtype of chronic prurigo for which the molecular basis and interplay between pathophysiologic mechanisms and clinical manifestations are poorly understood.
Methods
LOTUS-PN was a longitudinal observational study that included 54 participants from 11 centers and was designed to improve disease understanding. Protein expression, histology and RNA analyses were performed.
Results
Histologically, all patients had typical PN characteristics. Immunohistochemically, and on the mRNA level, expression in lesional versus non-lesional samples for IL-31 (p < 0.01) was significantly higher. In addition, immunohistochemistry showed higher expression of IL-31RA (p < 0.05), OSM (p < 0.05) and OSMRß (p < 0.01). PN lesional skin showed higher expression of Th2 and Th17/Th22 pathway markers. A correlation analysis of gene expression highlighted two groups of intra-marker correlations dividing the Th2 markers, the first containing barrier and regulatory genes and the other containing markers of general inflammation that correlated negatively and positively with Th17/Th22 genes, respectively. Correlations between gene expression and NRS scores were weak and involved genes associated with general inflammation (MMP12) and Th2 (IL10, CCL18, IL4R).
Conclusions
Our study confirms the role of Th2 signature in PN and the dominant role of IL31. Correlation analysis of gene expression showed differing relationships between subsets of the Th2 axis with Th1 and Th17/Th22 markers, highlighting the potential of different components of the Th2 pathway to interact with and modulate other immune axes.
期刊介绍：
The Journal of the European Academy of Dermatology and Venereology (JEADV) is a publication that focuses on dermatology and venereology. It covers various topics within these fields, including both clinical and basic science subjects. The journal publishes articles in different formats, such as editorials, review articles, practice articles, original papers, short reports, letters to the editor, features, and announcements from the European Academy of Dermatology and Venereology (EADV).
The journal covers a wide range of keywords, including allergy, cancer, clinical medicine, cytokines, dermatology, drug reactions, hair disease, laser therapy, nail disease, oncology, skin cancer, skin disease, therapeutics, tumors, virus infections, and venereology.
The JEADV is indexed and abstracted by various databases and resources, including Abstracts on Hygiene & Communicable Diseases, Academic Search, AgBiotech News & Information, Botanical Pesticides, CAB Abstracts®, Embase, Global Health, InfoTrac, Ingenta Select, MEDLINE/PubMed, Science Citation Index Expanded, and others.
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