State of Practice: A Report from the Inaugural SNIS Neurointerventional Oncology Summit.

Christopher C Young, Kazim H Narsinh, Stephen R Chen, Sameer A Ansari, Steven W Hetts, Frederick F Lang, Max Wintermark, Peter T Kan
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Abstract

Background: Over the past 25-years, progress in the treatment of central nervous system (CNS) tumors has been limited and outcomes for malignancies such as glioblastoma and diffuse intrinsic pontine glioma remain dismal. There has been great interest in harnessing endovascular neurointerventional techniques and to use the cerebral vasculature as a route for therapeutic delivery in neuro-oncology. Several selective intra-arterial clinical trials are currently underway targeting a range of CNS tumors with different therapeutic agents.

Methods: The Society of NeuroInterventional Surgery (SNIS) convened the inaugural Neurointerventional Oncology Summit which was held on April 26-27, 2024, at the University of Texas MD Anderson Cancer Center in Houston, Texas. The group consisted of neuro-interventionists, neurosurgeons, neuro-oncologists, neuroradiologists, basic scientists and industry representatives who are current practitioners in this emerging space. We report the current state of practice and our efforts to develop an organizational platform to treat patients suffering from CNS cancers and to advance research in this emerging field.

Key message: Endovascular surgical neuro-oncology is an emerging clinical endeavor which aims to provide novel therapeutic options for CNS cancers. Novel therapeutic agents including yttrium-90, oncolytic viruses and cellular immunotherapy are being tested as intraarterial therapy. Technological advances in imaging modalities, selective methods of blood brain barrier opening, and devices and catheters will aid advancement of the field. Multi-disciplinary cooperation and collaboration will be integral to the success of this endeavor.

Abbreviations: BBB = blood brain barrier; CAR = chimeric antigen receptor; DIPG = diffuse intrinsic pontine glioma; ESIA = endovascular selective intra-arterial; ESSIA = endovascular super-selective intra-arterial; FUS = focused ultrasound; GBM = glioblastoma; MSC-D24 = delta 24 oncolytic virus in mesenchymal stem cell; NK = natural killer; Y-90 = yttrium-90.

实践状态:来自首届SNIS神经介入肿瘤学峰会的报告。
背景:在过去的25年中,中枢神经系统(CNS)肿瘤的治疗进展有限,恶性肿瘤如胶质母细胞瘤和弥漫性固有脑桥胶质瘤的预后仍然令人沮丧。利用血管内神经介入技术和利用脑血管系统作为神经肿瘤学治疗递送的途径已经引起了极大的兴趣。一些选择性动脉内临床试验目前正在进行,针对一系列中枢神经系统肿瘤,使用不同的治疗药物。方法:神经介入外科学会(SNIS)于2024年4月26日至27日在德克萨斯州休斯顿的德克萨斯大学MD安德森癌症中心召开了首届神经介入肿瘤学峰会。该小组由神经介入学家、神经外科医生、神经肿瘤学家、神经放射学家、基础科学家和行业代表组成,他们是这一新兴领域的从业人员。我们报告目前的实践状态和我们为开发一个组织平台来治疗患有中枢神经系统癌症的患者和推进这一新兴领域的研究所做的努力。血管内外科神经肿瘤学是一项新兴的临床努力,旨在为中枢神经系统癌症提供新的治疗选择。包括钇-90、溶瘤病毒和细胞免疫疗法在内的新型治疗药物正在作为动脉内治疗进行试验。成像方式、选择性血脑屏障打开方法、设备和导管的技术进步将有助于该领域的发展。多学科合作和协作将是这一努力取得成功的必要条件。缩写:BBB =血脑屏障;嵌合抗原受体;DIPG =弥漫性内禀脑桥胶质瘤;ESIA =血管内选择性动脉内;ESSIA =血管内超选择性动脉内;FUS =聚焦超声;GBM =胶质母细胞瘤;间充质干细胞中δ 24溶瘤病毒的研究NK =自然杀手;y90 = y90。
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