Gd-EOB-DTPA-Enhanced Magnetic Resonance Imaging for Assessing Liver Function in Primary Biliary Cholangitis.

IF 1.1 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Current Medical Imaging Reviews Pub Date : 2025-06-23 DOI:10.2174/0115734056379090250611073434

Zhengjun Li, Fan Zhang, Weiting Lu, Chao Lu, Zheng Yuan, Zhongqiu Wang

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引用次数: 0

Abstract

Introduction: This study aimed to detect the performance of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for assessing primary biliary cholangitis (PBC).

Methods: Seventy-five patients with PBC were included in this prospective study. Shear wave elastography (SWE) and Gd-EOB-DTPA-enhanced MRI were conducted, and then the signal intensity ratio (SIR) and contrast enhancement index (CEI) in different phases, including portal venous phase (PVP), equilibrium phase (EP), and hepatobiliary phase (HBP), were calculated. Afterward, the results were compared with Child-Pugh grading and non-invasive liver fibrosis models using the Kruskal-Wallis H test or Chi-squared test. The area under the curve (AUC) was applied to evaluate the diagnostic performance of SIR_HBP, CEI_HBP, and SWE across different Child-Pugh grades.

Results: SWE (p<0.001), SIR _HBP (p<0.001), CEI_HBP (p<0.001), APRI (p=0.002), and FIB-4(p<0.001) showed significant differences in different Child-Pugh grades. Statistically significant differences were found in SIRHBP (p=0.005), CEI_HBP (p=0.010), and FIB-4 (p=0.001) of different SWE levels. For the diagnosis of Child-Pugh C, the AUC of SWE, SIR_HBP, and CEI_HBP were 0.889, 0.778, and 0.761, respectively. Correspondingly, the sensitivity was 75.0%, 64.4%, and 54.2%, and the specificity was 94.9%, 100%, and 100%, respectively. For the diagnosis of Child-Pugh B+C, the AUC of SWE, SIR_HBP, and CEI_HBP were 0.919, 0.809, and 0.814, respectively.

Discussion: Our study confirmed that Gd-EOB-DTPA-enhanced MRI is an effective and objective method for assessing liver function in patients with PBC.

Conclusion: SIR_HBP and CEI_HBP could be regarded as a novel imaging biomarker to evaluate liver function. Gd-EOB-DTPA-enhanced MRI and SWE outperformed serum-based models in sensitivity and specificity, strengthening the value of imaging in clinical decision-making.

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gd - eob - dtpa增强磁共振成像评估原发性胆道胆管炎的肝功能。

简介：本研究旨在检测钆乙氧基苄基二乙烯三胺五乙酸（Gd-EOB-DTPA）增强磁共振成像（MRI）在原发性胆道胆管炎（PBC）评估中的性能。方法：本前瞻性研究纳入75例PBC患者。行横波弹性成像（SWE）和gd - eob - dtpa增强MRI，计算门静脉期（PVP）、平衡期（EP）和肝胆期（HBP）不同阶段的信号强度比（SIR）和对比增强指数（CEI）。随后，使用Kruskal-Wallis H检验或卡方检验将结果与Child-Pugh分级和无创肝纤维化模型进行比较。采用曲线下面积（AUC）评价不同Child-Pugh分级的SIRHBP、CEIHBP和SWE的诊断效果。结果：不同SWE水平的SWE （pHBP）、pHBP (pHBP) （p=0.010）、FIB-4 （p=0.001）。对于Child-Pugh C的诊断，SWE、SIRHBP和CEIHBP的AUC分别为0.889、0.778和0.761。相应的，敏感性分别为75.0%、64.4%、54.2%，特异性分别为94.9%、100%、100%。对于Child-Pugh B+C的诊断，SWE、SIRHBP、CEIHBP的AUC分别为0.919、0.809、0.814。讨论：我们的研究证实gd - eob - dtpa增强MRI是评估PBC患者肝功能的有效和客观的方法。结论：SIRHBP和CEIHBP可作为评价肝功能的一种新的影像学生物标志物。gd - eob - dtpa增强MRI和SWE在敏感性和特异性上优于基于血清的模型，增强了成像在临床决策中的价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Medical Imaging Reviews 医学-核医学

CiteScore

2.60

自引率

0.00%

发文量

246

审稿时长

1 months

期刊介绍： Current Medical Imaging Reviews publishes frontier review articles, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on medical imaging dedicated to clinical research. All relevant areas are covered by the journal, including advances in the diagnosis, instrumentation and therapeutic applications related to all modern medical imaging techniques. The journal is essential reading for all clinicians and researchers involved in medical imaging and diagnosis.