Association Between Frailty and Albuminuria in the Community-Dwelling Geriatric Population.

IF 3.7 3区医学 Q2 GERIATRICS & GERONTOLOGY

Clinical Interventions in Aging Pub Date : 2025-06-27 eCollection Date: 2025-01-01 DOI:10.2147/CIA.S518738

Chih-Hsueh Lin, Che-Yi Chou, Tsai-Chung Li, Chiu-Shong Liu, Wen-Yuan Lin, Chia-Ing Li, Chuan-Wei Yang, Cheng-Chieh Lin

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引用次数: 0

Abstract

Aim: Elderly with frailty are more at risk of cardiovascular disease and all-cause mortality than the general population. Albuminuria is a risk factor for atherosclerosis, a major cause of frailty. We investigated the association between frailty and albuminuria in community-dwelling elderly.

Methods: This was a cross-sectional study for analyzing 1347 participants aged at least 65 years in the north district of Taichung, Taiwan. We defined the frailty phenotype as at least three characteristics: weight loss, exhaustion, weakness, slow walking speed, and decreased physical activity. We collected random urine and measured all participants' albumin/creatinine ratio (ACR). We analyzed the association between frailty and ACR using logistic regression with adjustments for confoundings.

Results: The average age of 1347 participants was 76 ± 7 years, and 649 (48.2%) were male. Two hundred and forty-two (18.7) participants were robust, 853 (63.3%) participants were pre-frail, and 242 (18%) were frail. One thousand sixty-four (79%) participants had an ACR < 30 mg/g; the highest ACR was 2825 mg/g. The odds ratio of ACR was 1.12 (95% confidence interval 1.05-1.25, p = 0.001) with adjustments for age, body mass index, estimated glomerular filtration rate, diabetes, liver function, and cholesterol.

Conclusion: Frailty is associated with urinary albuminuria in community-dwelling elderly, and this association is independent of traditional and non-traditional cardiovascular risk factors.

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在社区居住的老年人群中虚弱和蛋白尿的关系。

目的：与普通人群相比，体弱多病的老年人患心血管疾病和全因死亡的风险更高。蛋白尿是动脉粥样硬化的危险因素，是导致身体虚弱的主要原因。我们调查了社区居住老年人虚弱和蛋白尿之间的关系。方法：本研究为横断面研究，分析台湾台中北部地区年龄在65岁以上的1347名参与者。我们将虚弱表型定义为至少三个特征：体重减轻、疲惫、虚弱、步行速度慢和体力活动减少。我们随机收集尿液并测量所有参与者的白蛋白/肌酐比值（ACR）。我们使用逻辑回归分析了脆弱性和ACR之间的关系，并对混杂因素进行了调整。结果：1347人平均年龄76±7岁，男性649人，占48.2%。242名（18.7%）参与者健康，853名（63.3%）参与者体弱，242名（18%）参与者体弱。1664名（79%）参与者的ACR < 30mg /g；最高ACR为2825 mg/g。ACR的优势比为1.12(95%可信区间1.05-1.25,p = 0.001)，校正了年龄、体重指数、肾小球滤过率、糖尿病、肝功能和胆固醇。结论：老年社区居民身体虚弱与尿白蛋白尿相关，且与传统和非传统心血管危险因素无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.80

自引率

2.80%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.