Huiyu He, Mengling Wei, Jiao Zhong, Juan Wang, Lei Huang, Yajia Lan, Yang Zhang
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引用次数: 0
Abstract
Objective: To investigate the relationship between biological aging and the rate of cognitive decline in middle-aged and elderly populations.
Methods: Longitudinal tracking data of cognitive function were obtained from the China Health and Retirement Longitudinal Study (CHARLS). We employed the Klemera and Doubal method (KDM) to estimate biological age (BA), and calculate the biological aging index (BAI) and biological aging type (BAT). A multivariate linear regression model was employed to analyze the relationships between baseline BAI, BAT, and cognitive function scores. Based on the baseline analysis, a mixed-effects model was used to examine the longitudinal associations between baseline BAI, BAT, and cognitive function during follow-up.
Results: A total of 5897 participants were included in the study. BAI was found to be negatively associated with baseline cognitive function scores, with the partial regression coefficient (β) (95% CI) being -0.185 (-0.231, -0.139) (P < 0.001). Compared with the lagged aging group, the premature aging group had lower cognitive function scores (β [95% CI]: -0.741 [-0.966, -0.516]). For age and sex, for each additional year of baseline BAI, cognitive function scores declined by an average of 0.012 (95% CI: -0.019, -0.005) points per year after adjusting for age and sex, and declined by 0.011 (95% CI: -0.018, -0.004) points per year after adjusting for other covariates. Compared with participants with lagged aging, those with premature aging experienced, on average, an additional decline of 0.042 (95% CI: -0.075, 0.009) points per year in cognitive function scores after adjusting for age and sex alone, and by 0.039 (95% CI: -0.072, -0.007) points per year after adjusting for other covariates.
Conclusion: Biological aging affects the rate of cognitive decline in middle-aged and elderly populations. A higher BAI is associated with a faster decline in cognitive function. Compared with those with lagged aging, individuals with premature aging exhibit a more rapid rate of cognitive decline.
四川大学学报(医学版)Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
0.70
自引率
0.00%
发文量
8695
期刊介绍:
"Journal of Sichuan University (Medical Edition)" is a comprehensive medical academic journal sponsored by Sichuan University, a higher education institution directly under the Ministry of Education of the People's Republic of China. It was founded in 1959 and was originally named "Journal of Sichuan Medical College". In 1986, it was renamed "Journal of West China University of Medical Sciences". In 2003, it was renamed "Journal of Sichuan University (Medical Edition)" (bimonthly).
"Journal of Sichuan University (Medical Edition)" is a Chinese core journal and a Chinese authoritative academic journal (RCCSE). It is included in the retrieval systems such as China Science and Technology Papers and Citation Database (CSTPCD), China Science Citation Database (CSCD) (core version), Peking University Library's "Overview of Chinese Core Journals", the U.S. "Index Medica" (IM/Medline), the U.S. "PubMed Central" (PMC), the U.S. "Biological Abstracts" (BA), the U.S. "Chemical Abstracts" (CA), the U.S. EBSCO, the Netherlands "Abstracts and Citation Database" (Scopus), the Japan Science and Technology Agency Database (JST), the Russian "Abstract Magazine", the Chinese Biomedical Literature CD-ROM Database (CBMdisc), the Chinese Biomedical Periodical Literature Database (CMCC), the China Academic Journal Network Full-text Database (CNKI), the Chinese Academic Journal (CD-ROM Edition), and the Wanfang Data-Digital Journal Group.