Investigation of the causal relationship of saturated fat acids on heart stroke: evidence from two-sample Mendelian randomization.

IF 2.2 Q3 NUTRITION & DIETETICS

BMC Nutrition Pub Date : 2025-07-02 DOI:10.1186/s40795-025-01094-2

Danial Habibi, Iman Hamraz, Farshad Teymoori, Amir Hesam Saeidian, Hanifeh Mirtavoos-Mahyari, Qumars Kasnavi, Alireza Soleymani Taloubaghi, Homayoon Masoudi, Fereidoun Azizi, Maryam Sadat Daneshpour, Mehdi Hedayati, Mahdi Akbarzadeh, Marjan Mansourian

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Abstract

Background/aim: We conducted the Mendelian Randomization (MR) analysis to investigate the causal relationship between serum saturated fatty acids (SFAs) and the risk of heart stroke (HS).

Methods: The MRC-IEU Consortium provided summary statistics datasets related to SFAs, encompassing 64,979 individuals of European descent. Genetic variants associated with HF were identified using a GWAS dataset comprising 461,880 participants (cases = 7,055, controls = 454,825) of European descent from the UK Biobank. Generalized summary Mendelian Randomization (GSMR) assessed the potential association. Additionally, we performed a two-sample Mendelian Randomization (TSMR). The odds ratio (OR) with 95% confidence intervals (CIs) was indicated.

Results: The GSMR results suggested no significant between SFA and HS [OR = 1.002, 95% CI: 0.995, 1.009; P-value = 0.752]. TSMR revealed [ORIVW = 1.005, 95% CI: 0.998, 1.012; P-value = 0.169]. MR Egger (Q = 6.14, Q_pvalue = 0.292), IVW (Q = 6.24, Q_pvalue = 0.396; I2 = 18.7%) for heterogeneity test, and Egger intercept = 1.14 × e-4, p-value = 0.792 for pleiotropy test were performed. These findings remained consistent across various Mendelian Randomization methods, including IVW [OR = 1.005, 95% CI: 0.99-1.01, p-value = 0.169], Simple median [OR = 1.009, 95% CI: 0.99-1.02, p-value = 0.08], MR-Egger [OR = 1.001, 95% CI: 0.97-1.03, p-value = 0.97], Robust Adjusted Profile Score [OR = 1.005, 95% CI: 0.99-1.01, p-value = 0.167], MR-Lasso [OR = 1.005, 95% CI: 0.99-1.01, p-value = 0.169], Constrained maximum likelihood (MR-cML) [OR = 1.006, 95% CI: 0.99-1.01, p-value = 0.168], Weighted mode [OR = 1.01, 95% CI: 0.99-1.02, p-value = 0.279], Maximum-likelihood method [OR = 1.005, 95% CI: 0.99-1.01, p-value = 0.158].

Conclusion: Our MR study did not yield convincing evidence supporting the association of SFAs with HF risk. Future studies should focus on alternative approaches to investigate this association.

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饱和脂肪酸与心脏病因果关系的研究：来自双样本孟德尔随机化的证据。

背景/目的：我们通过孟德尔随机化（MR）分析来探讨血清饱和脂肪酸（SFAs）与心脏卒中（HS）风险之间的因果关系。方法：MRC-IEU联盟提供了与SFAs相关的汇总统计数据集，包括64,979名欧洲人后裔。使用来自英国生物银行的欧洲血统的461880名参与者（病例= 7055，对照组= 454825）的GWAS数据集确定与HF相关的遗传变异。广义总结孟德尔随机化（GSMR）评估了潜在的关联。此外，我们进行了双样本孟德尔随机化（TSMR）。比值比（OR）为95%置信区间（ci）。结果：GSMR结果显示SFA与HS之间无显著差异[OR = 1.002, 95% CI: 0.995, 1.009；p值= 0.752]。TSMR显示[ORIVW = 1.005, 95% CI: 0.998, 1.012；p值= 0.169]。Egger先生(Q = 6.14, Q_pvalue = 0.292), IVW (Q = 6.24, Q_pvalue = 0.396;异质性检验采用I2 = 18.7%)，多效性检验采用Egger截距= 1.14 × e-4， p值= 0.792。这些结果在各种孟德尔随机化方法中保持一致，包括IVW [OR = 1.005, 95% CI: 0.99-1.01， p值= 0.169]，简单中位数[OR = 1.009, 95% CI: 0.99-1.02， p值= 0.08],MR-Egger [OR = 1.001, 95% CI: 0.97-1.03， p值= 0.97]，稳健调整后的特征评分[OR = 1.005, 95% CI: 0.99-1.01， p值= 0.167],MR-Lasso [OR = 1.005, 95% CI: 0.99-1.01， p值= 0.169]，约束最大似然（MR-cML） [OR = 1.006, 95% CI: 0.99-1.01， p值= 0.169]：加权模式[OR = 1.01, 95% CI: 0.99-1.02， p值= 0.279]，最大似然法[OR = 1.005, 95% CI: 0.99-1.01， p值= 0.158]。结论：我们的MR研究没有提供令人信服的证据支持SFAs与HF风险的关联。未来的研究应侧重于研究这种关联的替代方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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