Forecasting the Global Burden of Peripheral Artery Disease from 2021 to 2050: A Population-Based Study.

IF 10.7 1区 综合性期刊 Q1 Multidisciplinary
Research Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI:10.34133/research.0702
Liling Deng, Chenzhen Du, Lu Liu, Yanzhong Wang, Haotian Gu, David G Armstrong, Joseph L Mills, Dirk Hochlenert, Huacong Deng, Junlin Ran, Yan Chen, Xiaoyan Jiang, Yu Ma, Qiu Chen, Wuquan Deng
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Abstract

Vascular disease is the leading cause of death worldwide. Predicting the burden of vascular disease and identifying modifiable key risk factors are critical for developing effective prevention strategies. This study aimed to project the global and regional burden of peripheral artery disease (PAD) from 2021 to 2050, with a specific focus on the impact of modifiable key risk factors and the potential benefits of their management. Compared to the 2021 Global Burden of Disease Study (GBD 2021), the number of PAD cases worldwide is projected to increase by 220% by 2050, reaching a staggering 360 million (95% uncertainty interval, 270 to 450). Age-standardized mortality is expected to double, while disability-adjusted life years (DALYs) are forecasted to rise from 19.7 to 33.1 per 100,000. Among individuals aged ≥65 years, PAD prevalence is projected to surge to 21.7% in women and 14.8% in men. Moreover, over 50% of PAD cases are expected to occur in low- and middle-income countries (LMICs). Metabolic diseases are anticipated to be the primary drivers of the rising PAD burden, with diabetes playing a key role in increasing PAD prevalence and severity. By effectively managing metabolic risk factors, age-standardized prevalence could be reduced by 36%, mortality by 17%, and DALYs by 10%. As metabolic risks, particularly diabetes, continue to rise alongside population aging, the global PAD burden is expected to increase substantially, especially in LMICs. Importantly, proactive metabolic risk management strategies have the potential to markedly alleviate the burden of vascular disease and reduce the growing geographic health disparities.

预测2021年至2050年全球外周动脉疾病负担:一项基于人群的研究
血管疾病是世界范围内导致死亡的主要原因。预测血管疾病的负担和确定可改变的关键危险因素对于制定有效的预防策略至关重要。本研究旨在预测2021年至2050年全球和区域外周动脉疾病(PAD)负担,特别关注可改变的关键风险因素的影响及其管理的潜在益处。与2021年全球疾病负担研究(GBD 2021)相比,到2050年,全球PAD病例数预计将增加220%,达到惊人的3.6亿(95%不确定区间,270至450)。年龄标准化死亡率预计将增加一倍,而残疾调整生命年(DALYs)预计将从每10万人19.7人增加到33.1人。在年龄≥65岁的人群中,PAD患病率预计将在女性中飙升至21.7%,在男性中飙升至14.8%。此外,预计50%以上的PAD病例发生在低收入和中等收入国家。预计代谢性疾病将是PAD负担增加的主要驱动因素,糖尿病在PAD患病率和严重程度增加中起着关键作用。通过有效管理代谢危险因素,年龄标准化患病率可降低36%,死亡率可降低17%,伤残调整生命年可降低10%。随着代谢风险,特别是糖尿病,随着人口老龄化继续上升,全球PAD负担预计将大幅增加,特别是在中低收入国家。重要的是,积极主动的代谢风险管理策略有可能显著减轻血管疾病的负担,并缩小日益扩大的地理健康差距。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Research
Research Multidisciplinary-Multidisciplinary
CiteScore
13.40
自引率
3.60%
发文量
0
审稿时长
14 weeks
期刊介绍: Research serves as a global platform for academic exchange, collaboration, and technological advancements. This journal welcomes high-quality research contributions from any domain, with open arms to authors from around the globe. Comprising fundamental research in the life and physical sciences, Research also highlights significant findings and issues in engineering and applied science. The journal proudly features original research articles, reviews, perspectives, and editorials, fostering a diverse and dynamic scholarly environment.
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