Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?

IF 9.2 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2025-07-01 DOI:10.1038/s41522-025-00749-z

Cristina Rosell-Cardona, John F Cryan, Gerard Clarke, Sarah Kittel-Schneider

引用次数: 0

Abstract

Depression is highly prevalent, with many patients not responding to existing treatments. The gut microbiota plays a key role in its pathophysiology, offering new therapeutic avenues. Human-based research is essential to uncover mechanisms and validate new targets. Given CNS inaccessibility, human induced pluripotent stem cells (hiPSCs) offer an innovative model. This review explores the emerging field of hiPSCs and their potential in advancing microbiota-gut-brain axis science and depression research.

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抑郁症的宿主-微生物组关系：人类诱导的多能干细胞能否在揭示机制中发挥作用？

抑郁症非常普遍，许多患者对现有的治疗没有反应。肠道微生物群在其病理生理中起着关键作用，提供了新的治疗途径。以人为基础的研究对于揭示机制和验证新靶点至关重要。鉴于中枢神经系统的不可接近性，人类诱导多能干细胞（hiPSCs）提供了一种创新的模型。本文综述了hiPSCs的新兴领域及其在促进微生物-肠-脑轴科学和抑郁症研究方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.