Age-associated defect in ADCC response to COVID-19 vaccine.

IF 6.9 1区 医学 Q1 IMMUNOLOGY
Benjamin L Sievers, Mazharul Altaf, Mark T K Cheng, Kimia Kamelian, Claire Cormie, Rainer Doffinger, Ravindra K Gupta
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引用次数: 0

Abstract

We investigated age-associated effects of SARS-CoV-2 vaccination in elderly individuals (n = 50, mean age 79) after six SARS-CoV-2 vaccine doses. While neutralization titers remained comparable across age groups, Fc-mediated effector functions declined with age. Individuals >80 demonstrated reduced antibody-dependent cellular cytotoxicity (ADCC), via a surrogate ADCC-signaling assay, correlating with diminished IgG1 binding. These findings highlight age-related impairments in Fc-mediated responses, with implications for immune protection and vaccine strategies in older populations.

ADCC对COVID-19疫苗反应的年龄相关缺陷
我们调查了老年人(n = 50,平均年龄79)接种6剂SARS-CoV-2疫苗后的年龄相关效应。虽然中和滴度在各年龄组之间保持可比性,但fc介导的效应物功能随着年龄的增长而下降。通过替代ADCC信号分析,个体bbbb80显示出抗体依赖性细胞毒性(ADCC)降低,与IgG1结合减少相关。这些发现强调了fc介导的应答中与年龄相关的损伤,对老年人群的免疫保护和疫苗策略具有重要意义。
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来源期刊
NPJ Vaccines
NPJ Vaccines Immunology and Microbiology-Immunology
CiteScore
11.90
自引率
4.30%
发文量
146
审稿时长
11 weeks
期刊介绍: Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.
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