A systematic review evaluating the effectiveness of nuclear medicine techniques in enhancing the diagnostic accuracy of stereotactic brain biopsies.

IF 2.5 3区医学 Q2 CLINICAL NEUROLOGY

Neurosurgical Review Pub Date : 2025-07-01 DOI:10.1007/s10143-025-03698-5

Athanasios Gkampenis, Eleni Romeo, Ioannis Koukoulithras, Marios Lampros, Spyridon Voulgaris, Andreas G Tzakos, George A Alexiou

{"title":"A systematic review evaluating the effectiveness of nuclear medicine techniques in enhancing the diagnostic accuracy of stereotactic brain biopsies.","authors":"Athanasios Gkampenis, Eleni Romeo, Ioannis Koukoulithras, Marios Lampros, Spyridon Voulgaris, Andreas G Tzakos, George A Alexiou","doi":"10.1007/s10143-025-03698-5","DOIUrl":null,"url":null,"abstract":"Purpose: The aim of the present systematic review is to assess the effectiveness of nuclear medicine methods to improve the diagnostic accuracy of stereotactic brain biopsies (SBB).Methods: A search in Medline, Cochrane, and Scopus databases until 22nd August 2024 was performed to retrieve relevant studies, aided by a manual search in Google Scholar. After applying predetermined inclusion and exclusion criteria, a data extraction was performed. The risk of bias and concerns regarding applicability were evaluated using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool.Results: Thirteen studies (9 prospective and 4 retrospective) with a total of 337 patients were included in this systematic review. There was a high risk of bias at least in one domain in all studies, while in 4 studies there were high concerns regarding applicability at least in one domain. Positron emission tomography (PET) was used in 12 studies and single photon emission computed tomography (SPECT) in 1 study to design the trajectories of the biopsies. A diagnosis was established through SBB in 282 out of 291 patients, while for the remaining 46 patients there was no relevant data in the studies. Two studies provided data on sensitivity (76 - 81.2 %), specificity (50 - 80 %), and Area Under the Curve (AUC) (56.2 - 89 %).Conclusion: Nuclear medicine has the potential to increase the diagnostic accuracy of SBB by improving targeting precision. Among the radiotracers, 11C-methionine emerged as the most effective, providing superior visualization of the metabolic active region of a brain tumor.","PeriodicalId":19184,"journal":{"name":"Neurosurgical Review","volume":"48 1","pages":"538"},"PeriodicalIF":2.5000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurosurgical Review","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10143-025-03698-5","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: The aim of the present systematic review is to assess the effectiveness of nuclear medicine methods to improve the diagnostic accuracy of stereotactic brain biopsies (SBB).

Methods: A search in Medline, Cochrane, and Scopus databases until 22^nd August 2024 was performed to retrieve relevant studies, aided by a manual search in Google Scholar. After applying predetermined inclusion and exclusion criteria, a data extraction was performed. The risk of bias and concerns regarding applicability were evaluated using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool.

Results: Thirteen studies (9 prospective and 4 retrospective) with a total of 337 patients were included in this systematic review. There was a high risk of bias at least in one domain in all studies, while in 4 studies there were high concerns regarding applicability at least in one domain. Positron emission tomography (PET) was used in 12 studies and single photon emission computed tomography (SPECT) in 1 study to design the trajectories of the biopsies. A diagnosis was established through SBB in 282 out of 291 patients, while for the remaining 46 patients there was no relevant data in the studies. Two studies provided data on sensitivity (76 - 81.2 %), specificity (50 - 80 %), and Area Under the Curve (AUC) (56.2 - 89 %).

Conclusion: Nuclear medicine has the potential to increase the diagnostic accuracy of SBB by improving targeting precision. Among the radiotracers, ¹¹C-methionine emerged as the most effective, providing superior visualization of the metabolic active region of a brain tumor.

查看原文本刊更多论文

评价核医学技术在提高立体定向脑活检诊断准确性方面的有效性的系统综述。

目的：评价核医学方法提高立体定向脑活检（SBB）诊断准确性的有效性。方法：检索Medline、Cochrane和Scopus数据库，检索截止到2024年8月22日的相关研究，并借助谷歌Scholar人工检索。应用预定的纳入和排除标准后，进行数据提取。使用诊断准确性研究质量评估2 （QUADAS-2）工具评估偏倚风险和适用性问题。结果：本系统综述纳入13项研究（9项前瞻性研究，4项回顾性研究），共337例患者。在所有研究中，至少有一个领域存在高偏倚风险，而在4项研究中，至少有一个领域的适用性受到高度关注。12项研究使用正电子发射断层扫描（PET）， 1项研究使用单光子发射计算机断层扫描（SPECT）来设计活检的轨迹。291例患者中有282例通过SBB确诊，而其余46例患者在研究中没有相关数据。两项研究提供了敏感性（76 - 81.2%）、特异性（50 - 80%）和曲线下面积（56.2 - 89%）的数据。结论：核医学有可能通过提高靶向精度来提高SBB的诊断准确性。在放射性示踪剂中，11c -蛋氨酸是最有效的，为脑肿瘤的代谢活跃区提供了优越的可视化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neurosurgical Review 医学-临床神经学

CiteScore

5.60

自引率

7.10%

发文量

191

审稿时长

6-12 weeks

期刊介绍： The goal of Neurosurgical Review is to provide a forum for comprehensive reviews on current issues in neurosurgery. Each issue contains up to three reviews, reflecting all important aspects of one topic (a disease or a surgical approach). Comments by a panel of experts within the same issue complete the topic. By providing comprehensive coverage of one topic per issue, Neurosurgical Review combines the topicality of professional journals with the indepth treatment of a monograph. Original papers of high quality are also welcome.