Dimeric copper peptide incorporated hydrogel for promoting diabetic wound healing.

IF 15.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications Pub Date : 2025-07-01 DOI:10.1038/s41467-025-61141-1

Rui Cong, Chengyu Deng, Pengwei Li, Yiwei Tang, Jinfan Hou, Jiehui Zhao, Qili Wang, Yingying Chen, Jiasheng Tu, Xiqun Jiang, Lei Jiang

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Abstract

Diabetic wounds require continuous and coordinated modulation of the microenvironment concurrent with tissue regeneration, which remains a significant challenge. As a proof of concept, we herein propose to use dimeric copper peptide (D-CuP) for diabetic wound treatment. The D-CuP is synthesized and then incorporated into a reactive oxygen species (ROS)-responsive hydrogel matrix to improve therapeutic compliance, culminating in the formulation of G/D-CuP. Compared to monomer copper peptide (M-CuP), a wound healing agent, D-CuP exhibits multivalency, enhanced biological stability against proteases, and broad biological activities. Meanwhile, the hydrogel matrix, exhibiting ROS-scavenging capabilities, has been engineered to be an intelligent drug reservoir for wound-responsive release of D-CuP at the wound site while simultaneously attenuating inflammatory responses. Ultimately, the G/D-CuP group demonstrates superior therapeutic efficacy, achieving 97.2% closure of infected wounds.

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二聚体铜肽结合水凝胶促进糖尿病伤口愈合。

糖尿病伤口需要持续和协调的微环境调节，同时组织再生，这仍然是一个重大的挑战。作为概念证明，我们在此提出使用二聚铜肽（D-CuP）用于糖尿病伤口治疗。合成D-CuP，然后将其掺入活性氧（ROS）反应的水凝胶基质中，以提高治疗依从性，最终形成G/D-CuP。与伤口愈合剂单体铜肽（M-CuP）相比，D-CuP具有多价性、抗蛋白酶的生物稳定性增强和广泛的生物活性。同时，具有ros清除能力的水凝胶基质已被设计成一种智能药物储存器，可在伤口部位释放D-CuP，同时减轻炎症反应。最终，G/D-CuP组表现出优越的治疗效果，97.2%的感染伤口愈合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.