The medial prefrontal cortex encodes procedural rules as sequential neuronal activity dynamics.

IF 2.9 3区 医学 Q2 NEUROSCIENCES
Shuntaro Ohno, Masanori Nomoto, Kaoru Inokuchi
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引用次数: 0

Abstract

The prefrontal cortex plays a crucial role in procedural rule learning; however, the specific neuronal mechanism through which it represents rules is unknown. We hypothesized that sequential neuronal activities in the prefrontal cortex encode these rules. To investigate this, we recorded neuronal activities in the medial prefrontal cortex of mice during rule learning using Ca2+ imaging. We utilized a method based on convolutional negative matrix factorization, iSeq, to automatically detect temporal neuronal sequences in the recorded data. As rule learning advanced, these neuronal sequences began to encode critical information for rule execution. In mice that had mastered the rule, the dynamics of neuronal sequences could predict success and failure of reward acquisition. Furthermore, the composition of cell populations within the neuronal sequences was rearranged throughout the learning process. These findings suggest that as animals learn a rule, the medial prefrontal cortex continually updates its neuronal sequences to assign significance to behavioural actions crucial for reward acquisition.

内侧前额叶皮层将程序规则编码为顺序的神经元活动动态。
前额叶皮层在程序规则学习中起着至关重要的作用;然而,它代表规则的具体神经元机制尚不清楚。我们假设前额皮质的连续神经元活动编码了这些规则。为了研究这一点,我们使用Ca2+成像记录了小鼠在规则学习期间内侧前额叶皮层的神经元活动。我们使用了一种基于卷积负矩阵分解(iSeq)的方法来自动检测记录数据中的时间神经元序列。随着规则学习的发展,这些神经元序列开始为规则执行编码关键信息。在掌握了这一规则的老鼠身上,神经元序列的动态可以预测获得奖励的成功和失败。此外,神经元序列内细胞群的组成在整个学习过程中被重新排列。这些发现表明,当动物学习规则时,内侧前额叶皮层会不断更新其神经元序列,以赋予对获得奖励至关重要的行为行为以意义。
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来源期刊
Molecular Brain
Molecular Brain NEUROSCIENCES-
CiteScore
7.30
自引率
0.00%
发文量
97
审稿时长
>12 weeks
期刊介绍: Molecular Brain is an open access, peer-reviewed journal that considers manuscripts on all aspects of studies on the nervous system at the molecular, cellular, and systems level providing a forum for scientists to communicate their findings. Molecular brain research is a rapidly expanding research field in which integrative approaches at the genetic, molecular, cellular and synaptic levels yield key information about the physiological and pathological brain. These studies involve the use of a wide range of modern techniques in molecular biology, genomics, proteomics, imaging and electrophysiology.
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