Klotho protein in Alzheimer's disease: Diet leading to immortality?

IF 3.4 3区 医学 Q2 NEUROSCIENCES
Kamil Walczak, Weronika Kołodziejczyk, Magdalena Pszczołowska, Magdalena Kozłowska, Jan Aleksander Beszłej, Jerzy Leszek
{"title":"Klotho protein in Alzheimer's disease: Diet leading to immortality?","authors":"Kamil Walczak, Weronika Kołodziejczyk, Magdalena Pszczołowska, Magdalena Kozłowska, Jan Aleksander Beszłej, Jerzy Leszek","doi":"10.1177/13872877251350125","DOIUrl":null,"url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most common cause of dementia, leading to progressive cognitive decline and premature death. Despite decades of research, the exact cause of AD remains unknown, and current treatments only slow disease progression without addressing its root cause. Recent studies suggest that endogenous factors such as the Klotho protein may have neuroprotective properties and influence AD progression. This review aims to explore the role of Klotho protein in AD, with a particular focus on its biological functions, expression, and potential therapeutic implications. Additionally, it examines the relationship between Klotho levels and dietary patterns. A literature review was conducted to analyze existing research on Klotho protein, its neuroprotective effects, and its correlation with different dietary factors in the context of AD. Evidence suggests that Klotho protein plays a crucial role in cellular metabolism and neuroprotection. Higher levels of Klotho have been linked to better cognitive function and reduced neurodegeneration. Emerging research also indicates that certain dietary patterns, particularly the Mediterranean diet, may positively influence Klotho expression. Klotho protein represents a promising therapeutic target in AD, potentially slowing disease progression through its neuroprotective effects. Further research is needed to better understand the mechanisms regulating Klotho levels, particularly the impact of diet, and how they can be leveraged for AD prevention and treatment.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251350125"},"PeriodicalIF":3.4000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Alzheimer's Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/13872877251350125","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Alzheimer's disease (AD) is the most common cause of dementia, leading to progressive cognitive decline and premature death. Despite decades of research, the exact cause of AD remains unknown, and current treatments only slow disease progression without addressing its root cause. Recent studies suggest that endogenous factors such as the Klotho protein may have neuroprotective properties and influence AD progression. This review aims to explore the role of Klotho protein in AD, with a particular focus on its biological functions, expression, and potential therapeutic implications. Additionally, it examines the relationship between Klotho levels and dietary patterns. A literature review was conducted to analyze existing research on Klotho protein, its neuroprotective effects, and its correlation with different dietary factors in the context of AD. Evidence suggests that Klotho protein plays a crucial role in cellular metabolism and neuroprotection. Higher levels of Klotho have been linked to better cognitive function and reduced neurodegeneration. Emerging research also indicates that certain dietary patterns, particularly the Mediterranean diet, may positively influence Klotho expression. Klotho protein represents a promising therapeutic target in AD, potentially slowing disease progression through its neuroprotective effects. Further research is needed to better understand the mechanisms regulating Klotho levels, particularly the impact of diet, and how they can be leveraged for AD prevention and treatment.

阿尔茨海默病中的Klotho蛋白:饮食导致长生不老?
阿尔茨海默病(AD)是痴呆症最常见的病因,导致认知能力逐渐下降和过早死亡。尽管经过数十年的研究,阿尔茨海默病的确切病因仍不清楚,目前的治疗方法只是减缓疾病进展,而没有解决其根本原因。最近的研究表明,内源性因子如Klotho蛋白可能具有神经保护特性并影响AD的进展。本文旨在探讨Klotho蛋白在AD中的作用,特别关注其生物学功能、表达和潜在的治疗意义。此外,它还研究了Klotho水平与饮食模式之间的关系。本文通过文献综述,分析AD背景下Klotho蛋白的研究现状、其神经保护作用及其与不同饮食因素的相关性。有证据表明,Klotho蛋白在细胞代谢和神经保护中起着至关重要的作用。较高水平的Klotho与更好的认知功能和减少神经变性有关。新兴研究还表明,某些饮食模式,特别是地中海饮食,可能对Klotho表达产生积极影响。Klotho蛋白是阿尔茨海默病的一个有希望的治疗靶点,可能通过其神经保护作用减缓疾病进展。需要进一步的研究来更好地了解调节Klotho水平的机制,特别是饮食的影响,以及如何利用它们来预防和治疗AD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease 医学-神经科学
CiteScore
6.40
自引率
7.50%
发文量
1327
审稿时长
2 months
期刊介绍: The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信