Comparative analysis of plasma BNP and NT-proBNP levels, and NT-proBNP/BNP ratio in patients with chronic kidney disease.

IF 4.6 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Hypertension Research Pub Date : 2025-07-01 DOI:10.1038/s41440-025-02272-2

Hideki Fujii, Shunsuke Goto

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引用次数: 0

Abstract

Both B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are clinically used for diagnosing and monitoring heart failure. However, their levels are influenced by several factors, and their impacts on chronic kidney disease (CKD) patients remain unclear. This study included 1036 patients who visited the Nephrology division at our hospital between 2014 and 2015. Plasma BNP, NT-proBNP levels and the BNP/NT-proBNP ratio were measured at each CKD stage, and their correlation with clinical factors were analyzed. This study included 1037 patients with stage 1 to stage 5D CKD (CKD 1-2, n = 114; CKD 3, n = 256; CKD 4, n = 266; CKD 5, n = 298; CKD 5D, n = 102). Levels of plasma BNP and NT-proBNP levels and the NT-proBNP/BNP ratio increased, and the correlation between BNP and NT-proBNP levels weakened with declining kidney function. Although various clinical factors were found to be significantly correlated with these parameters, multivariate analysis showed that male gender and hemoglobin, phosphate, and parathyroid hormone levels were significantly correlated with both plasma BNP and NT-proBNP levels. Notably, a higher NT-proBNP/BNP ratio was significantly associated with increased cardiovascular events in patients with CKD stages 4 and 5. As plasma BNP and NT-proBNP levels are influenced by various factors in patients with CKD, careful interpretation of these parameters is essential. In patients with advanced-stage CKD, the NT-proBNP/BNP ratio may be a useful predictor of CVD development.

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慢性肾病患者血浆BNP、NT-proBNP水平及NT-proBNP/BNP比值的比较分析

b型利钠肽（BNP）和n端前b型利钠肽（NT-proBNP）均在临床上用于心力衰竭的诊断和监测。然而，它们的水平受到几个因素的影响，它们对慢性肾脏疾病（CKD）患者的影响尚不清楚。本研究纳入了2014年至2015年在我院肾内科就诊的1036例患者。测定CKD各阶段血浆BNP、NT-proBNP水平及BNP/NT-proBNP比值，并分析其与临床因素的相关性。本研究纳入1037例1至5D期CKD患者(CKD 1-2, n = 114；CKD 3, n = 256；CKD 4, n = 266；CKD 5, n = 298；CKD 5D, n = 102)。血浆BNP和NT-proBNP水平及NT-proBNP/BNP比值升高，BNP和NT-proBNP水平的相关性随着肾功能下降而减弱。虽然多种临床因素与这些参数有显著相关性，但多因素分析显示，男性性别、血红蛋白、磷酸盐和甲状旁腺激素水平与血浆BNP和NT-proBNP水平均有显著相关性。值得注意的是，较高的NT-proBNP/BNP比率与CKD 4期和5期患者心血管事件的增加显著相关。由于CKD患者血浆BNP和NT-proBNP水平受到多种因素的影响，因此仔细解释这些参数至关重要。在晚期CKD患者中，NT-proBNP/BNP比值可能是CVD发展的有用预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hypertension Research 医学-外周血管病

CiteScore

7.40

自引率

16.70%

发文量

249

审稿时长

3-8 weeks

期刊介绍： Hypertension Research is the official publication of the Japanese Society of Hypertension. The journal publishes papers reporting original clinical and experimental research that contribute to the advancement of knowledge in the field of hypertension and related cardiovascular diseases. The journal publishes Review Articles, Articles, Correspondence and Comments.