Targeting the redox neuroinflammatory nexus: insights into Alzheimer's and Parkinson's diseases.

IF 5.3 2区医学 Q2 IMMUNOLOGY

Inflammopharmacology Pub Date : 2025-07-02 DOI:10.1007/s10787-025-01831-w

Loganathan Chandramani Priya Dharshini, Kunnathur Murugesan Sakthivel, K Gilbert Ross Rex, Rajan Radha Rasmi

引用次数: 0

Abstract

Neurodegenerative diseases, including Alzheimer's and Parkinson's, are characterized by the progressive deterioration of neuronal structure and function within the central and peripheral nervous systems. Among the multifactorial mechanisms implicated in their pathogenesis, oxidative stress and chronic neuroinflammation have emerged as pivotal contributors. An imbalance in redox homeostasis, marked by excessive generation of reactive oxygen species (ROS) and impaired antioxidant defenses, leads to sustained activation of inflammatory pathways and exacerbation of neuronal injury. This intricate interplay, known as the redox-neuroinflammatory nexus, constitutes a central axis in the onset and progression of neurodegeneration. This review underscores the critical role of redox imbalance in neurodegenerative processes and provides a comprehensive analysis of the oxidative stress and inflammation crosstalk in Alzheimer's and Parkinson's diseases, offering insights into potential therapeutic targets.

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靶向氧化还原神经炎症关系：对阿尔茨海默病和帕金森病的见解。

神经退行性疾病，包括阿尔茨海默病和帕金森病，其特征是中枢和周围神经系统内神经元结构和功能的进行性恶化。在涉及其发病机制的多因素机制中，氧化应激和慢性神经炎症已成为关键因素。氧化还原稳态失衡，以活性氧（ROS）的过量产生和抗氧化防御受损为特征，导致炎症途径的持续激活和神经元损伤的加剧。这种复杂的相互作用，被称为氧化还原-神经炎症联系，构成了神经退行性变的发生和进展的中心轴。这篇综述强调了氧化还原失衡在神经退行性过程中的关键作用，并对阿尔茨海默病和帕金森病中的氧化应激和炎症串串进行了全面分析，为潜在的治疗靶点提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY

CiteScore

8.00

自引率

3.40%

发文量

200

期刊介绍： Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]