Nicholas C Schena, Kassandra M Baker, Anna A Stark, Derek P Thomas, Ian A Cleary
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引用次数: 0
Abstract
The fungal pathogen Candida albicans produces numerous surface proteins involved in adhesion. Many of these adhesins are specific to different morphological forms. Strains that are unable to form hyphae are generally impaired in their ability to adhere to surfaces and to form biofilms. To better understand the function of one of these adhesins, Als3p, in the context of yeast-locked strains, we expressed ALS3 in strains with altered expression of one of two genes that are part of a regulatory circuit, BRG1 and NRG1. The mutant BRG1 and NRG1 strains we examined were phenotypically similar. We observed that ALS3 expression improved the adhesion of both strains to glass but that only one had altered biofilm forming ability, which was decreased.
期刊介绍：
Unlike journals which specialize ever more narrowly, Folia Microbiologica (FM) takes an open approach that spans general, soil, medical and industrial microbiology, plus some branches of immunology. This English-language journal publishes original papers, reviews and mini-reviews, short communications and book reviews. The coverage includes cutting-edge methods and promising new topics, as well as studies using established methods that exhibit promise in practical applications such as medicine, animal husbandry and more. The coverage of FM is expanding beyond Central and Eastern Europe, with a growing proportion of its contents contributed by international authors.
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