{"title":"Remarkable Response to Vismodegib in a Locally Advanced Basal Cell Carcinoma on the Nose.","authors":"Evan Mak, Shannon Buck","doi":"10.12788/cutis.1228","DOIUrl":null,"url":null,"abstract":"<p><p>Basal cell carcinoma (BCC) is the most common cancer in the world, and its incidence continues to rise. Known risk factors for BCC include chronic UV exposure, advanced age, and genetic predisposition. A large majority of BCC cases have an altered Hedgehog (Hh) signaling pathway. When a large BCC develops on the face, it can pose unique treatment challenges due to functional and cosmetic considerations-even with Mohs micrographic surgery (MMS). Traditional treatment options may be limited, prompting the use of targeted therapies such as vismodegib for unresectable cases. Vismodegib, an Hh inhibitor, is approved by the US Food and Drug Administration for treatment of locally advanced or metastatic BCC. This case report details the successful management of a large BCC on the nose of an elderly patient using vismodegib.</p>","PeriodicalId":11195,"journal":{"name":"Cutis","volume":"115 5","pages":"E9-E11"},"PeriodicalIF":2.1000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cutis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12788/cutis.1228","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Basal cell carcinoma (BCC) is the most common cancer in the world, and its incidence continues to rise. Known risk factors for BCC include chronic UV exposure, advanced age, and genetic predisposition. A large majority of BCC cases have an altered Hedgehog (Hh) signaling pathway. When a large BCC develops on the face, it can pose unique treatment challenges due to functional and cosmetic considerations-even with Mohs micrographic surgery (MMS). Traditional treatment options may be limited, prompting the use of targeted therapies such as vismodegib for unresectable cases. Vismodegib, an Hh inhibitor, is approved by the US Food and Drug Administration for treatment of locally advanced or metastatic BCC. This case report details the successful management of a large BCC on the nose of an elderly patient using vismodegib.
期刊介绍：
Published since 1965, Cutis is a peer-reviewed clinical journal for the dermatologist, allergist, and general practitioner. The journal is published monthly and focuses on concise clinical articles that present the practical side of dermatology. Referenced in Index Medicus/MEDLINE, it is respected and enjoyed by both specialists and derm-active generalists, enabling its readers to get what they need quickly and efficiently. Furthermore, Cutis is read by more physicians actively involved in the day-to-day treatment of dermatologic conditions than any other dermatology publication. Covering a broad range of pertinent and timely topics, Cutis is written and edited by industry leaders. For information on article submissions, please see our Information for Authors.
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