Sexually Transmitted Infections and Risk of Human Immunodeficiency Virus Transmission.

IF 3.7 2区医学 Q2 INFECTIOUS DISEASES

Current HIV/AIDS Reports Pub Date : 2025-07-02 DOI:10.1007/s11904-025-00749-w

Amanda Maguire Wilkerson, Jun Tao, Philip A Chan

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Abstract

Purpose of the review: Sexually transmitted infections (STIs) include a diverse set of bacteria, viruses, parasites, and other pathogens that can facilitate transmission of Human Immunodeficiency Virus (HIV). However, the extent to which STIs increase HIV risk and public health approaches to address this are still evolving.

Recent findings: Compelling evidence suggests STIs increase the risk of HIV acquisition and transmission. STIs may lead to higher rates of HIV infection through multiple mechanisms including inflammation and disruption of the epithelium, facilitating immune cells which are targets of HIV, and increased viral load shedding in those that have HIV. While previous STI control efforts have shown mixed effectiveness in reducing HIV incidence, the success of doxycycline prophylaxis for preventing bacterial STIs offers a promising approach that may help prevent HIV at the population-level. STIs significantly increase the risk of HIV acquisition and transmission. Increased understanding of public health approaches, which both contribute to STI control and also prevent HIV transmission, is needed.

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性传播感染和人类免疫缺陷病毒传播的风险。

综述目的：性传播感染（STIs）包括多种细菌、病毒、寄生虫和其他可促进人类免疫缺陷病毒（HIV）传播的病原体。然而，性传播感染增加艾滋病毒风险的程度以及解决这一问题的公共卫生办法仍在不断发展。最新发现：令人信服的证据表明，性传播感染增加了艾滋病毒感染和传播的风险。性传播感染可能通过多种机制导致更高的艾滋病毒感染率，包括炎症和上皮破坏，促进作为艾滋病毒目标的免疫细胞，以及增加艾滋病毒感染者的病毒载量减少。虽然以前的性传播感染控制工作在降低艾滋病毒发病率方面显示出好坏参半的效果，但强力霉素预防细菌性传播感染的成功提供了一种有希望的方法，可能有助于在人群水平上预防艾滋病毒。性传播感染大大增加了艾滋病毒感染和传播的风险。需要增进对公共卫生办法的了解，这些办法既有助于性传播感染控制，也有助于预防艾滋病毒传播。

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来源期刊

Current HIV/AIDS Reports INFECTIOUS DISEASES-

CiteScore

8.10

自引率

2.20%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of HIV/AIDS. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antiretroviral therapies, behavioral aspects of management, and metabolic complications and comorbidity. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.