Mechanisms and Therapeutic Implications of ncRNAs in Regulating the PD-1/PD-L1 Axis Across Cancers.

IF 1.6 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Combinatorial chemistry & high throughput screening Pub Date : 2025-06-30 DOI:10.2174/0113862073384743250617062430

Huilin Jian, Xitai Li, Xiaoyong Lei, Shengsong Tang, Xiaoyan Yang

引用次数: 0

Abstract

Cancer remains one of the most challenging health issues worldwide. Thus, there is an urgent need to discover effective treatments for cancer. Immune checkpoint blockade targeting the PD-1/PD-L1 axis has revolutionized cancer therapy, yet resistance and limited clinical efficacy remain significant challenges. Emerging evidence highlights ncRNAs as upstream regulators of PD-1/PD-L1, offering novel therapeutic opportunities. This review systematically examines the role of miRNAs, lncRNAs, and circRNAs in modulating PD-1/PD-L1 signaling across diverse cancers, emphasizing their mechanisms and clinical implications. We further discuss the potential of ncRNAs as biomarkers and therapeutic targets to overcome immune evasion and enhance immunotherapy efficacy.

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ncrna在癌症中调节PD-1/PD-L1轴的机制和治疗意义。

癌症仍然是全世界最具挑战性的健康问题之一。因此，迫切需要发现治疗癌症的有效方法。靶向PD-1/PD-L1轴的免疫检查点阻断已经彻底改变了癌症治疗，但耐药性和有限的临床疗效仍然是重大挑战。新出现的证据表明，ncrna是PD-1/PD-L1的上游调节因子，提供了新的治疗机会。本综述系统地研究了mirna、lncrna和circrna在多种癌症中调节PD-1/PD-L1信号传导中的作用，强调了它们的机制和临床意义。我们进一步讨论了ncrna作为生物标志物和治疗靶点的潜力，以克服免疫逃避和提高免疫治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Combinatorial chemistry & high throughput screening 化学-生化研究方法

CiteScore

3.10

自引率

5.60%

发文量

327

审稿时长

7.5 months

期刊介绍： Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal: Target identification and validation Assay design, development, miniaturization and comparison High throughput/high content/in silico screening and associated technologies Label-free detection technologies and applications Stem cell technologies Biomarkers ADMET/PK/PD methodologies and screening Probe discovery and development, hit to lead optimization Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) Chemical library design and chemical diversity Chemo/bio-informatics, data mining Compound management Pharmacognosy Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products) Natural Product Analytical Studies Bipharmaceutical studies of Natural products Drug repurposing Data management and statistical analysis Laboratory automation, robotics, microfluidics, signal detection technologies Current & Future Institutional Research Profile Technology transfer, legal and licensing issues Patents.