Evidence on the link between hypothyroidism and non-alcoholic fatty liver disease: an updated systematic review.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

BMC Endocrine Disorders Pub Date : 2025-07-01 DOI:10.1186/s12902-025-01977-2

Nazanin Pourseyedi, Sara Arefhosseini, Helda Tutunchi, Mehrangiz Ebrahimi-Mameghani

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引用次数: 0

Abstract

Background: Numerous studies have investigated the relationship between hypothyroidism and non-alcoholic fatty liver disease (NAFLD), while the underlying mechanisms are not well understood. This systematic review evaluated the mentioned relationship among non-diabetic adults.

Methods: This systematic review was written in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was conducted using PubMed, Scopus, Web of Science, and Google Scholar until January 2024. After a critical analysis, 29 observational studies were included in the present systematic review.

Results: The available observational evidence suggests a potential association between hypothyroidism and NAFLD. Regarding this complex relationship, patients with hypothyroidism may be more likely to develop NAFLD compared to those with normal thyroid function. Several factors are involved in the development of hypothyroidism-induced NAFLD.

Conclusions: Thyroid hormones regulate energy and metabolism, suggesting their relevance in NAFLD. Increased awareness and optimized strategies are needed for mutual screening and managing thyroid disease and NAFLD coexistence.

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甲状腺功能减退与非酒精性脂肪肝之间联系的证据：一项最新的系统综述

背景：大量研究调查了甲状腺功能减退与非酒精性脂肪性肝病（NAFLD）之间的关系，但其潜在机制尚不清楚。本系统综述在非糖尿病成人中评估了上述关系。方法：本系统评价按照系统评价和荟萃分析的首选报告项目（PRISMA）指南撰写。到2024年1月，我们使用PubMed、Scopus、Web of Science和b谷歌Scholar进行了全面的文献检索。经过批判性分析，本系统综述纳入了29项观察性研究。结果：现有的观察证据表明甲状腺功能减退与NAFLD之间存在潜在的关联。鉴于这种复杂的关系，与甲状腺功能正常的患者相比，甲状腺功能减退患者可能更容易发生NAFLD。几个因素涉及到甲状腺功能减退引起的NAFLD的发展。结论：甲状腺激素调节能量和代谢，提示其与NAFLD相关。需要提高认识和优化策略，以相互筛查和管理甲状腺疾病和NAFLD共存。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-

CiteScore

4.40

自引率

0.00%

发文量

280

审稿时长

>12 weeks

期刊介绍： BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.