Jiaqi Huang, Qiaozhi Jiang, Jiaxuan Liu, Guocheng Mei, Renchuan Tao
{"title":"Two oral verrucous carcinomas in a patient with oral graft vs. host disease- recurrent verrucous carcinoma: a case report.","authors":"Jiaqi Huang, Qiaozhi Jiang, Jiaxuan Liu, Guocheng Mei, Renchuan Tao","doi":"10.1186/s12903-025-06333-3","DOIUrl":null,"url":null,"abstract":"<p><p>Patients who undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT) frequently experience immunodeficiency, predisposing them to graft-versus-host disease (GVHD) and viral infection. The oral cavity is a common organ affected by chronic GVHD(cGVHD), which can lead to the development of secondary malignant tumors such as oral squamous cell carcinoma (OSCC). Verrucous carcinoma is a low-grade variant of SCC with specific morphologic, cytokinetic and clinical features. It is a locally aggressive tumour and does not metastasize to regional lymph nodes or to distant sites. This case report describes a patient with cGVHD following allo-HSCT who developed extensive oral verrucous carcinoma in the oral mucosa. This observation underscores the importance of regular oral examinations for transplant recipients, particularly those with cGVHD, to monitor HPV infection and the potential development of verrucous carcinoma.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"968"},"PeriodicalIF":3.1000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217826/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Oral Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12903-025-06333-3","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Patients who undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT) frequently experience immunodeficiency, predisposing them to graft-versus-host disease (GVHD) and viral infection. The oral cavity is a common organ affected by chronic GVHD(cGVHD), which can lead to the development of secondary malignant tumors such as oral squamous cell carcinoma (OSCC). Verrucous carcinoma is a low-grade variant of SCC with specific morphologic, cytokinetic and clinical features. It is a locally aggressive tumour and does not metastasize to regional lymph nodes or to distant sites. This case report describes a patient with cGVHD following allo-HSCT who developed extensive oral verrucous carcinoma in the oral mucosa. This observation underscores the importance of regular oral examinations for transplant recipients, particularly those with cGVHD, to monitor HPV infection and the potential development of verrucous carcinoma.
期刊介绍:
BMC Oral Health is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the mouth, teeth and gums, as well as related molecular genetics, pathophysiology, and epidemiology.