Offering e-cigarettes for smoking cessation and reduction in people with mental illness (ESCAPE): Protocol for a randomized controlled trial

IF 5.3 1区医学 Q1 PSYCHIATRY

Addiction Pub Date : 2025-07-01 DOI:10.1111/add.70115

Dimitra Kale, Emma Beard, Yan Ding, Jodi Pervin, Qi Wu, Catherine Arundel, Steve Parrott, Paul Galdas, Michelle Horspool, Simon Hough, Gregor Russell, Suzy Ker, Elena Ratschen, Lion Shahab

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引用次数: 0

Abstract

Background and aims

Despite a steady decline in smoking rates across the United Kingdom (UK) over the past decades, substantial tobacco-related inequalities persist, particularly among individuals with mental illness. Smoking prevalence in this group has remained largely unchanged, highlighting a major public health concern. This protocol outlines a trial aimed at addressing this issue by evaluating the effectiveness of offering an electronic cigarette (e-cigarette) starter kit for smoking cessation and harm reduction as an adjunct to usual care to adults who smoke with mental illness treated in the community.

Design

Two-arm parallel randomized controlled superiority trial.

Setting

A minimum of eleven UK National Health Service mental health Trusts or general practices.

Participants

Adults who smoke with a diagnosis of mental illness treated in the community.

Intervention and comparator

Participants will be randomly allocated (1 : 1) to receive: (i) an e-cigarette starter kit, a brief demonstration and both verbal and written information on e-cigarette use as an adjunct to usual care; or (ii) usual care alone.

Measurements

The primary outcome is 7-day point prevalence carbon monoxide-validated abstinence, assessed six months after study enrolment or target quit date. Secondary outcomes include: 6-month continuous abstinence defined by Russell Standard, self-reported smoking abstinence at 1 month, ≥50% smoking reduction (cigarettes/day) at 1 and 6 months, mental health symptoms and general mood and physical symptoms at 1 and 6 months, cost-effectiveness of the intervention and adherence to and satisfaction with the intervention.

Comments

This will be the first large-scale study in the UK to assess the effectiveness and cost-effectiveness of providing an e-cigarette starter kit for smoking cessation and harm reduction in people with mental illness. Results will inform policy and practice related to supporting smoking cessation for this population.

Abstract Image

查看原文本刊更多论文

为精神疾病患者戒烟和减少吸烟提供电子烟（ESCAPE）：一项随机对照试验方案。

背景和目的：尽管在过去的几十年里，英国的吸烟率稳步下降，但与烟草相关的不平等现象仍然存在，特别是在患有精神疾病的个体中。这一群体的吸烟率基本保持不变，突出了一个重大的公共卫生问题。本议定书概述了一项旨在解决这一问题的试验，通过评估向在社区接受治疗的患有精神疾病的成年吸烟者提供戒烟和减少危害的电子烟入门工具包作为常规护理的辅助措施的有效性。设计：双臂平行随机对照优势试验。设置：至少有11个英国国民健康服务精神健康信托机构或普通诊所。参与者：在社区接受治疗的被诊断为精神疾病的吸烟成年人。干预和比较：参与者将被随机分配（1:1）接受：(i)一套电子烟入门套件，一个简短的演示以及作为常规护理辅助的电子烟使用的口头和书面信息；或（ii）单独的常规护理。测量：主要结果是7天点患病率一氧化碳验证戒断，在研究入组或目标戒烟日期6个月后评估。次要结局包括：罗素标准定义的连续戒烟6个月，1个月时自我报告的戒烟情况，1和6个月时吸烟量减少≥50%（支/天），1和6个月时的精神健康症状和一般情绪和身体症状，干预的成本-效果以及对干预的依从性和满意度。评论：这将是英国第一个大规模的研究，以评估为精神疾病患者提供戒烟和减少危害的电子烟入门套件的有效性和成本效益。研究结果将为支持这一人群戒烟的相关政策和实践提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Addiction 医学-精神病学

CiteScore

10.80

自引率

6.70%

发文量

319

审稿时长

3 months

期刊介绍： Addiction publishes peer-reviewed research reports on pharmacological and behavioural addictions, bringing together research conducted within many different disciplines. Its goal is to serve international and interdisciplinary scientific and clinical communication, to strengthen links between science and policy, and to stimulate and enhance the quality of debate. We seek submissions that are not only technically competent but are also original and contain information or ideas of fresh interest to our international readership. We seek to serve low- and middle-income (LAMI) countries as well as more economically developed countries. Addiction’s scope spans human experimental, epidemiological, social science, historical, clinical and policy research relating to addiction, primarily but not exclusively in the areas of psychoactive substance use and/or gambling. In addition to original research, the journal features editorials, commentaries, reviews, letters, and book reviews.