Jianxia Lyu, Li Yin, Hao Zhang, Shichuan Zhang, Yunhua Jing, Qing Yang, Aiping Wang
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引用次数: 0
Abstract
Objectives: Self-reported health-related quality of life (HRQoL) is a critical metric for evaluating clinical outcomes. Although the HRQoL of patients with nasopharyngeal carcinoma (NPC) has been widely studied, the performance of these assessments in clinical practice remains uncertain, and there is a significant gap in the quality evaluation of the scales used. This review aimed to systematically evaluate self-reported HRQoL scales for patients with NPC, thereby providing guidelines for the informed selection of assessment tools.
Design: A systematic review based on the Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) methodology and following the PRISMA guidelines.
Methods: PubMed, Web of Science, Embase, CINAHL, PsycINFO, CNKI, SinoMed, and WanFang databases were systematically searched from their inception until August 2024. The included studies must report the assessment of measurement properties of HRQoL scales designed for NPC. Two authors independently screened the eligible literature, extracted data, and evaluated their methodological and psychometric quality. The measurement properties of HRQoL scales for NPC were evaluated according to COSMIN systematic review guidelines. Additionally, the GRADE approach was used to grade the quality of evidence.
Results: Among 17 instruments across 19 studies, all demonstrated adequate content validity, construct validity, and internal consistency. However, information on cross-cultural validity, criterion validity, reliability, hypothesis testing, and responsiveness was limited. High-quality evidence on psychometric properties was provided for HRQoL instruments for Cancer Patients-Nasopharyngeal Cancer (QLICP-NA), the Functional Assessment of Cancer Therapy-Nasopharyngeal (FACT-NP), and the Quality of Life Scale for Nasopharyngeal Carcinoma Patients Version 2 (QoL-NPC V2).
Conclusion: The measurement characteristics of QLICP-NA, FACT-NP, and QoL-NPC V2 scales were comprehensively assessed, exhibiting good methodological quality, strong measurement attributes, and robust supporting evidence. Therefore, these scales are recommended for evaluating the quality of life of patients with NPC. However, further validation of the remaining assessment tools is required.
Relevance to Clinical Practice: Our findings will help healthcare professionals select suitable instruments for patients with NPC.
目的：自我报告的健康相关生活质量（HRQoL）是评估临床结果的关键指标。虽然鼻咽癌（NPC）患者的HRQoL已经得到了广泛的研究，但这些评估在临床实践中的表现仍然不确定，并且所使用的量表的质量评价存在显着差距。本综述旨在系统评估鼻咽癌患者自我报告的HRQoL量表，从而为评估工具的明智选择提供指导。设计：根据基于共识的健康测量工具选择标准（COSMIN）方法并遵循PRISMA指南进行系统审查。方法：系统检索PubMed、Web of Science、Embase、CINAHL、PsycINFO、CNKI、SinoMed、万方等数据库自建站至2024年8月。纳入的研究必须报告为鼻咽癌设计的HRQoL量表的测量特性评估。两位作者独立筛选符合条件的文献，提取数据，并评估其方法学和心理测量学质量。根据COSMIN系统评价指南评价鼻咽癌HRQoL量表的测量特性。此外，采用GRADE方法对证据质量进行分级。结果：19项研究的17种工具均表现出足够的内容效度、结构效度和内部一致性。然而，关于跨文化效度、标准效度、信度、假设检验和反应性的信息有限。为鼻咽癌患者HRQoL量表（QLICP-NA）、鼻咽癌治疗功能评估（FACT-NP）和鼻咽癌患者生活质量量表第2版（QoL-NPC V2）提供了高质量的心理测量特性证据。结论：QLICP-NA、FACT-NP和QoL-NPC V2量表的测量特征得到了全面评价，方法学质量好，测量属性强，支持证据有力。因此，这些量表被推荐用于评估鼻咽癌患者的生活质量。然而，需要进一步验证剩余的评估工具。与临床实践的相关性：我们的研究结果将帮助医疗保健专业人员为鼻咽癌患者选择合适的仪器。
期刊介绍：
The European Journal of Cancer Care aims to encourage comprehensive, multiprofessional cancer care across Europe and internationally. It publishes original research reports, literature reviews, guest editorials, letters to the Editor and special features on current issues affecting the care of cancer patients. The Editor welcomes contributions which result from team working or collaboration between different health and social care providers, service users, patient groups and the voluntary sector in the areas of:
- Primary, secondary and tertiary care for cancer patients
- Multidisciplinary and service-user involvement in cancer care
- Rehabilitation, supportive, palliative and end of life care for cancer patients
- Policy, service development and healthcare evaluation in cancer care
- Psychosocial interventions for patients and family members
- International perspectives on cancer care
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