Effects of acute exercise on prefrontal cortex oxygenation in substance use disorders: A systematic review and meta-analysis of fNIRS studies

IF 2.3 3区医学 Q2 PSYCHIATRY

Mental Health and Physical Activity Pub Date : 2025-06-27 DOI:10.1016/j.mhpa.2025.100704

Daniel A.R. Cabral , Dongshi Wang , Nora L. Nock , Bruno Malagodi , Karam Nusair , Ghada Nusair , Marcelo Bigliassi , Zacarya Elbash , Kell Grandjean da Costa , Eduardo Fontes , Garrett J. Posey , Vagner D.O. Tavares

{"title":"Effects of acute exercise on prefrontal cortex oxygenation in substance use disorders: A systematic review and meta-analysis of fNIRS studies","authors":"Daniel A.R. Cabral , Dongshi Wang , Nora L. Nock , Bruno Malagodi , Karam Nusair , Ghada Nusair , Marcelo Bigliassi , Zacarya Elbash , Kell Grandjean da Costa , Eduardo Fontes , Garrett J. Posey , Vagner D.O. Tavares","doi":"10.1016/j.mhpa.2025.100704","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and aims</h3><div>Physical activity (PA) has been found to improve cognitive functions, which are often impaired in people with substance use disorders (SUD). These effects may be due to increased blood flow and oxygenation to the prefrontal cortex (PFC). However, results have been equivocal. This systematic review and meta-analysis aimed to synthesize the current literature on acute exercise on PFC oxygenation, as measured by functional near-infrared spectroscopy (fNIRS), in individuals with SUD.</div></div><div><h3>Methods</h3><div>The review identified 13 studies comprising 457 individuals with SUD that examined the effects of acute exercise on PFC oxygenation with fNIRS. The meta-analysis included 7 studies (12 effect sizes) and evaluated the effects of acute exercise on changes in oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HHb) (pre vs. post exercise).</div></div><div><h3>Results</h3><div>Most studies were of poor quality (high or moderate risk of bias), and there was high heterogeneity related to exercise type (e.g., aerobic), intensity, and designs. The meta-analysis for HbO revealed that the summary effect was not statistically significant (<em>g</em> = −0.59; 95 %CI: [-3.04, 1.85]) and there was substantial heterogeneity (I<sup>2</sup> = 97.64 %, p < 0.001). For HHb, the summary effect size was not statistically significant (<em>g</em> = 0.003; 95 % CI: [-0.96, 0.95]), and heterogeneity was high (I<sup>2</sup> = 78.12 %, p = 0.002). Subgroup analyses revealed no statistically significant differences based on exercise intensity.</div></div><div><h3>Conclusion</h3><div>Future research should focus on high-quality randomized trials with crossover designs. In addition to the effects of chronic exercise interventions, which have not been well explored, may lead to more substantive changes in PFC oxygenation and, hence, larger effect sizes.</div></div>","PeriodicalId":51589,"journal":{"name":"Mental Health and Physical Activity","volume":"29 ","pages":"Article 100704"},"PeriodicalIF":2.3000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mental Health and Physical Activity","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1755296625000353","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Background and aims

Physical activity (PA) has been found to improve cognitive functions, which are often impaired in people with substance use disorders (SUD). These effects may be due to increased blood flow and oxygenation to the prefrontal cortex (PFC). However, results have been equivocal. This systematic review and meta-analysis aimed to synthesize the current literature on acute exercise on PFC oxygenation, as measured by functional near-infrared spectroscopy (fNIRS), in individuals with SUD.

Methods

The review identified 13 studies comprising 457 individuals with SUD that examined the effects of acute exercise on PFC oxygenation with fNIRS. The meta-analysis included 7 studies (12 effect sizes) and evaluated the effects of acute exercise on changes in oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HHb) (pre vs. post exercise).

Results

Most studies were of poor quality (high or moderate risk of bias), and there was high heterogeneity related to exercise type (e.g., aerobic), intensity, and designs. The meta-analysis for HbO revealed that the summary effect was not statistically significant (g = −0.59; 95 %CI: [-3.04, 1.85]) and there was substantial heterogeneity (I² = 97.64 %, p < 0.001). For HHb, the summary effect size was not statistically significant (g = 0.003; 95 % CI: [-0.96, 0.95]), and heterogeneity was high (I² = 78.12 %, p = 0.002). Subgroup analyses revealed no statistically significant differences based on exercise intensity.

Conclusion

Future research should focus on high-quality randomized trials with crossover designs. In addition to the effects of chronic exercise interventions, which have not been well explored, may lead to more substantive changes in PFC oxygenation and, hence, larger effect sizes.

查看原文本刊更多论文

急性运动对物质使用障碍患者前额皮质氧合的影响：fNIRS研究的系统回顾和荟萃分析

研究发现，身体活动（PA）可以改善认知功能，而认知功能通常在物质使用障碍（SUD）患者中受损。这些影响可能是由于前额皮质（PFC）的血流量和氧合增加。然而，结果是模棱两可的。本系统综述和荟萃分析旨在综合目前关于急性运动对心力衰竭患者PFC氧合的影响的文献，通过功能近红外光谱（fNIRS）测量。方法本综述确定了13项研究，包括457名SUD患者，用fNIRS检测急性运动对PFC氧合的影响。荟萃分析包括7项研究（12个效应大小），并评估急性运动对氧合血红蛋白（HbO）和脱氧血红蛋白（hbb）变化的影响（运动前与运动后）。结果大多数研究质量较差（高或中等偏倚风险），并且在运动类型（如有氧）、强度和设计方面存在高度异质性。HbO的荟萃分析显示，总结效应无统计学意义(g = - 0.59；95% CI:[-3.04, 1.85])，且存在显著异质性(I2 = 97.64%, p <；0.001)。对于hbb，总效应大小无统计学意义(g = 0.003；95%置信区间:[-0.96,0.95]),异质性高(I2 = 78.12%, p = 0.002)。亚组分析显示，基于运动强度的差异无统计学意义。结论今后的研究应以高质量的随机试验为主，采用交叉设计。此外，长期运动干预的影响尚未得到很好的探索，可能会导致PFC氧合发生更实质性的变化，因此，效应规模更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Mental Health and Physical Activity PSYCHIATRY-

CiteScore

6.70

自引率

6.40%

发文量

审稿时长

32 days

期刊介绍： The aims of Mental Health and Physical Activity will be: (1) to foster the inter-disciplinary development and understanding of the mental health and physical activity field; (2) to develop research designs and methods to advance our understanding; (3) to promote the publication of high quality research on the effects of physical activity (interventions and a single session) on a wide range of dimensions of mental health and psychological well-being (eg, depression, anxiety and stress responses, mood, cognitive functioning and neurological disorders, such as dementia, self-esteem and related constructs, psychological aspects of quality of life among people with physical and mental illness, sleep, addictive disorders, eating disorders), from both efficacy and effectiveness trials;