Flavonoids and butanolides from the bark of Machilus robusta and their bioactivities

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-07-03 DOI:10.1016/j.phytol.2025.103007

Rui-Qi Liu , Shan-Shan Ling , Xian-Da Hu , Bing Peng , Yan-Ru Li

引用次数: 0

Abstract

One new flavanone glycoside, named (2R,3R)-dihydrokaempferol-5-O-α-L-arabinopyranoside (1), together with 11 known compounds, was isolated from the ethanol extract of Machilus robusta bark. Their structures were elucidated by a combination of spectroscopic and chemical analysis. Compounds 4 and 5 showed neuroprotective activity against serum deprivation induced PC12 cell damage by increasing the cell viability from 66.6 ± 9.2 % to 81.96 ± 8.13 % and 78.38 ± 11.65 %, respectively, at a concentration of 10 µM. And at the same concentration, compound 4 showed stronger hepatoprotective activity against WB-F344 cell damage induced by DL-galactosamine than that of the positive drug bicyclol. In addition, compound 3 showed certain antioxidant activity inhibiting Fe^2 + -cystine-induced rat liver microsomal lipid peroxidation.

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黄酮类化合物和丁醇内酯及其生物活性研究

从马钱子树皮的乙醇提取物中分离到一个新的黄酮苷，命名为(2R,3R)-二氢山奈酚-5- o -α- l-阿拉伯吡喃苷(1)，并分离到11个已知化合物。用光谱分析和化学分析相结合的方法对其结构进行了鉴定。化合物4和图5显示神经活动对血清剥夺诱导PC12细胞损伤通过增加细胞生存能力从66.6 ±9.2  % 81.96 ±8.13   %和78.38±11.65  %,分别在10浓度 µM。在相同浓度下，化合物4对dl -半乳糖胺诱导的WB-F344细胞损伤的保护作用强于阳性药物双环醇。此外，化合物3对Fe2 + -胱氨酸诱导的大鼠肝微粒体脂质过氧化有一定的抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.