Opening the ‘GATE’ for human cytomegalovirus entry

IF 20.5 1区生物学 Q1 MICROBIOLOGY

Nature Microbiology Pub Date : 2025-07-02 DOI:10.1038/s41564-025-02044-1

引用次数: 0

Abstract

A newly identified human cytomegalovirus cell entry complex couples the canonical envelope glycoprotein H with UL116 (a mimic of glycoprotein L) to incorporate the immune-evasion molecule UL141 into virions. This complex (named gH-associated tropism and entry (GATE)-3) facilitates infection of endothelial cells and is a promising target for vaccines.

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打开人类巨细胞病毒进入的“大门”

一种新发现的人巨细胞病毒细胞进入复合物将典型包膜糖蛋白H与UL116（糖蛋白L的模拟物）偶联，将免疫逃避分子UL141纳入病毒粒子。这种复合物（被称为gh相关趋向性和进入(GATE)-3）促进内皮细胞感染，是疫苗的一个有希望的靶点。

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来源期刊

Nature Microbiology Immunology and Microbiology-Microbiology

CiteScore

44.40

自引率

1.10%

发文量

226

期刊介绍： Nature Microbiology aims to cover a comprehensive range of topics related to microorganisms. This includes: Evolution: The journal is interested in exploring the evolutionary aspects of microorganisms. This may include research on their genetic diversity, adaptation, and speciation over time. Physiology and cell biology: Nature Microbiology seeks to understand the functions and characteristics of microorganisms at the cellular and physiological levels. This may involve studying their metabolism, growth patterns, and cellular processes. Interactions: The journal focuses on the interactions microorganisms have with each other, as well as their interactions with hosts or the environment. This encompasses investigations into microbial communities, symbiotic relationships, and microbial responses to different environments. Societal significance: Nature Microbiology recognizes the societal impact of microorganisms and welcomes studies that explore their practical applications. This may include research on microbial diseases, biotechnology, or environmental remediation. In summary, Nature Microbiology is interested in research related to the evolution, physiology and cell biology of microorganisms, their interactions, and their societal relevance.