Promise without practice — charting the path forward for bladder cancer biomarkers

IF 12.1 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Urology Pub Date : 2025-07-02 DOI:10.1038/s41585-025-01064-0

Marie-Pier St-Laurent, Peter C. Black

引用次数: 0

Abstract

Bladder cancer is a biologically heterogeneous disease, and ongoing efforts in biomarker research aim to support personalized treatment approaches. Circulating tumour DNA is approaching clinical integration through prospective trials, whereas other markers remain investigational owing to technical limitations, inconsistent findings and lack of validation. Rigorous biomarker-driven trials and cost-effectiveness studies are needed to enable the integration of molecular tools into routine practice. Biomarkers might ultimately lead to rational treatment de-escalation or escalation, improving outcomes while minimizing harm and cost.

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没有实践的承诺-绘制膀胱癌生物标志物的前进道路

膀胱癌是一种生物学异质性疾病，生物标志物研究的持续努力旨在支持个性化治疗方法。通过前瞻性试验，循环肿瘤DNA正在接近临床整合，而由于技术限制、不一致的发现和缺乏验证，其他标记仍处于研究阶段。需要严格的生物标志物驱动试验和成本效益研究，才能将分子工具整合到常规实践中。生物标志物可能最终导致合理的治疗降级或升级，改善结果，同时最大限度地减少伤害和成本。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Urology 医学-泌尿学与肾脏学

CiteScore

12.50

自引率

2.60%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.